Pain relief techniques for knee surgery recovery
Randomized, Double-Blinded Study to Evaluate the Analgesic Efficacy of Anterior Femoral Cutaneous Nerve Block and/or Genicular Nerve Block When Combined With Adductor Canal (Saphenous) Nerve Block After Total Knee Arthroplasty
This study is testing a mix of nerve blocks to see if they can help people recover from knee surgery with less pain and fewer side effects than regular pain medications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 144 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Cedars-Sinai Medical Center Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT02548104 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a combination of nerve blocks, specifically the Anterior Femoral Block (AFB), Adductor Canal Block (ACB), and Genicular Block (iPACK), in managing postoperative pain after total knee arthroplasty (TKA). The approach aims to provide targeted analgesia while minimizing the side effects associated with traditional opioid pain management. By focusing on specific nerve pathways, the study seeks to enhance pain relief during movement and rehabilitation, ultimately improving recovery outcomes for patients. Participants will receive either the ACB alone or the combination of ACB and iPACK to assess the comparative efficacy of these techniques.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-90 who are undergoing total knee arthroplasty and are classified as ASA Physical Status 1-3.
Not a fit: Patients who have contraindications to regional anesthesia or those undergoing bilateral TKA or revision surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative pain and improve recovery times for patients undergoing knee surgery.
How similar studies have performed: Previous studies have shown promising results with similar regional anesthesia techniques, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-90 yrs 2. The American Society of Anesthesiologists (ASA) Physical Status 1-3 3. Either gender Exclusion Criteria: 1. Refusal to participate in the study 2. Age\< 18 yrs, or\> 90 yrs 3. General anesthesia 4. Bilateral TKA, or revision of TKA 5. Contraindications to regional blockage including but not limited to: * Patient refusal to regional blockade * Infection at the site of needle insertion * Systemic infection * Bleeding diathesis or coagulopathy (as diagnosed by history or laboratory evaluation)
Where this trial is running
Los Angeles, California
- Cedars Sinai Medical Center — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Roya Yumul, M.D.,PhD. — Department of Anesthesiology
- Study coordinator: Roya Yumul, M.D.,PhD.
- Email: Roya.Yumul@cshs.org
- Phone: 310-423-5841
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.