Pain-relief medicines after tooth extractions: dipyrone vs paracetamol in adults
Official title: Hematological Alterations Associated With the Use of Dipyrone Versus Paracetamol After Dental Extractions: a Double-blind, Randomized Clinical Trial
Run by Federal University of Juiz de Fora · NCT07918040 · Data updated 2026-11-12
This study tests whether dipyrone or paracetamol, used for pain after dental extractions, have different effects on blood counts and safety in healthy adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Federal University of Juiz de Fora Academic / other |
| Drugs / interventions | methotrexate |
| Locations | 1 site (Juiz de Fora, Minas Gerais) |
| Status | Recruiting |
| Started | November 13, 2026 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07918040 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults 18-60 who require bilateral tooth extractions and have no contraindications to dipyrone or paracetamol.
✕Probably not a fit
Participants with conditions or medications that affect blood counts or organ function or who do not complete both periods may not derive benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This phase 4 trial uses a randomized, double-blind, cross-over design in adults needing bilateral dental extractions. Each participant will receive either dipyrone or paracetamol for 7 days in one period and the other drug in a separate period after a washout; blood tests will monitor blood cells, liver and kidney function, and blood pressure, along with reporting side effects. The primary focus is changes in white and red blood cells, neutrophils, platelets, and overall safety. The study is conducted at the Federal University of Juiz de Fora in Brazil and uses identical capsules to maintain blinding. Eligible participants are healthy adults aged 18-60 requiring bilateral extractions, with strict exclusion criteria to minimize confounding factors.
Why it matters
Potential benefit: If successful, the trial could clarify the hematologic and systemic safety of dipyrone relative to paracetamol after dental procedures.
How similar studies have gone: Previous broader research supports safety monitoring of hematologic and hepatic parameters with these medications, but direct cross-over data after dental procedures is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy patients of both sexes, aged 18 to 60 years * Indication for bilateral tooth extraction in similar positions Exclusion Criteria: * History of allergy to dipyrone or paracetamol. * Insufficient or improperly completed study records. * Failure to return for the second tooth extraction. * Use of warfarin, bupropion, efavirenz, methadone, cyclosporine, tacrolimus, sertraline, valproate, methotrexate, acetylsalicylic acid, or other non-steroidal anti-inflammatory drugs (NSAIDs), analgesics, or corticosteroids on a continuous basis (for 7 days or longer) prior to surgery. * Systemic conditions that could interfere with hematological outcomes, including diagnosed hematological disorders, coagulopathies, severe liver or kidney disease, or active autoimmune diseases at the time of the appointment.
Where it's running
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Faculty of Dentistry at the Federal University of Juiz de Fora (UFJF)
Juiz de Fora, Minas Gerais, Brazil Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.