Pain management using liposomal bupivacaine in knee surgery

A Analgesic Study of Adductor Canal &IPACK Block with Liposomal Bupivacaine in Knee Arthroplasty ：A Randomized，Double-controlled，Parallel-controlled，Single-center Study

This study is testing if using liposomal bupivacaine for pain relief during knee surgery can help patients feel less pain and recover faster without affecting their muscle strength.

Quick facts

• Phase: PHASE4
• Study type: Interventional
• Enrollment: 90 (estimated)
• Ages: 18 Years to 79 Years
• Sex: All
• Sponsor: Nanjing First Hospital, Nanjing Medical University (other)
• Locations: 1 site (Nanjing, Jiangsu)
• Trial ID: NCT06145165 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of adductor canal and iPACK blocks using liposomal bupivacaine for postoperative pain relief in patients undergoing knee arthroplasty. It aims to determine if this approach can prolong sensory nerve block duration without compromising muscle strength, thereby improving recovery outcomes and reducing hospital stays. The study will assess various indicators, including pain scores, quality of recovery, and complications, to provide evidence-based recommendations for analgesic regimens in knee surgery.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18-79 undergoing unilateral total knee arthroplasty or unicondylar joint replacement.

Not a fit: Patients with severe neurological diseases, mental disorders, or significant comorbidities may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance postoperative pain management and recovery for knee arthroplasty patients.

How similar studies have performed: Other studies have shown promising results with nerve blocks for pain management, but the specific use of liposomal bupivacaine in this context is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Age 18-79 years.
2. Patients undergoing unilateral total knee arthroplasty or unicondylar joint replacement.
3. Normal diet.
4. ASA grade I\~Ⅲ;
5. BMI 18-30kg /m2.
6. No intraspinal anesthesia contraindications.

Exclusion Criteria:

1. Patients with severe neurological diseases.
2. Hearing and speech impaired.
3. Preoperative gastric emptying disorders, such as gastrointestinal obstruction, gastroesophageal reflux, or previous gastrointestinal surgery, etc.
4. Patients with severe renal insufficiency or other severe metabolic diseases.
5. Mental disorders, alcoholism or a history of drug abuse.
6. The surgical time is greater than 3 hours.
7. Puncture site infection, abnormal coagulation function, and local anesthetic allergy.

Where this trial is running

Nanjing, Jiangsu

• Nanjing First Hospital — Nanjing, Jiangsu, China (RECRUITING)

Study contacts

• Study coordinator: Liu Han

Conditions: Liposomal Bupivacaine, Postoperative Recovery, Unilateral Knee Arthroplasty