Pain management after surgery for peritoneal cancer
Quadratus Lumborum Block for Analgesia After Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy (CRS and HIPEC): a Double-blind Randomized Controlled Trial
This study is testing if a special pain relief technique can help people who have surgery for peritoneal cancer feel less pain and use fewer opioids after their operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Gangnam Severance Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05597683 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a transmuscular quadratus lumborum block (QL block) in reducing postoperative pain for patients undergoing cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC). Participants will be randomly assigned to receive either the QL block with multimodal analgesia or standard multimodal analgesia alone. The primary outcome measured will be opioid consumption in the first 24 hours post-surgery, while secondary outcomes will include pain scores, time to first rescue analgesic, quality of recovery, and length of hospital stay. The study aims to improve pain management strategies for this patient population.
Who should consider this trial
Good fit: Ideal candidates are adult patients scheduled for cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy.
Not a fit: Patients with allergies to local anesthetics, chronic pain, or those unable to communicate may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative pain and opioid consumption for patients undergoing CRS and HIPEC.
How similar studies have performed: Other studies have shown promising results with similar regional anesthesia techniques, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Adult patients who are scheduled to undergo cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy (CRS and HIPEC) Exclusion Criteria: 1. Allergy to local anesthetics or fentanyl 2. Chronic pain 3. Drug abuse 4. Patients who are unable to use patient-controlled analgesia 5. Skin infection at site for quadratus lomborum block 6. pregnant or breatfeeding women 7. Patients who are unable to communicate
Where this trial is running
Seoul
- Gangnam Severance Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Young Song — Gangnam Severance Hospital
- Study coordinator: SunKyung Park
- Email: mayskpark@yuhs.ac
- Phone: 82-2-2019-4601
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.