Clinical trial Recruiting at 1 site Phase2; Phase3 Interventional

Oxygenated gel treatment for oral ulcers

Official title: Efficacy of Oxygenated Gel Therapy in the Management of Oral Aphthous Ulcers: A Randomized Controlled Clinical Trial

Run by British University In Egypt · NCT06910579 · Data updated 2026-11-12

This study tests whether an oxygenated gel can help heal mouth ulcers better than a corticosteroid paste in people who have these painful sores.

Quick facts

PhasePhase2; Phase3
Study typeInterventional
SexAll
Enrollment30 (estimated)
SponsorBritish University In Egypt
Academic / other
Locations1 site (Al Sherouk City, Cairo Governorate)
StatusRecruiting
StartedMarch 15, 2025
Main results expectedJanuary 30, 2027
Study endsJuly 12, 2027
Registry record updatedOctober 15, 2026
Trial IDNCT06910579 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are systemically healthy individuals with a single chronic aphthous ulcer measuring 6 mm or less.

Probably not a fit

Patients with multiple ulcers, major aphthous stomatitis, or those with systemic diseases may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial compares the effectiveness of an oxygenated gel and a corticosteroid paste in treating chronic aphthous ulcers. Patients are divided into two groups, with one group applying the oxygenated gel twice daily and the other using a corticosteroid paste four times daily for a week. The study aims to evaluate the healing process and symptom relief at various intervals post-treatment. Both groups consist of patients with single, clinically diagnosed ulcers measuring 6 mm or less.

Why it matters

Potential benefit: If successful, this treatment could provide a more effective and less invasive option for managing painful oral ulcers.

How similar studies have gone: Previous studies have shown varying success with topical treatments for aphthous ulcers, but the specific use of oxygenated gel is less commonly tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinically diagnosed patients with chronic aphthous stomatitis measuring ≤6 mm in size in the oral cavity and who gave written consent for participation.
* Only single ulcers were considered for the study.
* Systemically healthy patients.

Exclusion Criteria:

* The study excluded patients with a history of associated systemic disease.
* Cases of chronic aphthous stomatitis (major), lesions of herpetic form, numerous aphthae, and smoking.
* Patients with a history of hypersensitivity to the used agents.
* Pregnancy and lactation

Where it's running

  • British University in Egypt
    Al Sherouk City, Cairo Governorate, Egypt
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.