Oxygen Reserve Index monitoring to detect early desaturation during anesthesia in older adults having cancer surgery
Official title: The Effectiveness of Oxygen Reserve Index in Early Detection of Desaturation in Geriatric Patients Scheduled for Oncological Surgery; a Prospective, Observational Study.
Run by Ankara City Hospital Bilkent · NCT07326293 · Data updated 2026-11-12
This project will test whether the Oxygen Reserve Index (ORI) gives clinicians earlier warning of falling oxygen levels during induction and intubation in people aged 65 and older having elective cancer surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years to 100 Years |
| Sex | All |
| Enrollment | 44 (estimated) |
| Sponsor | Ankara City Hospital Bilkent Academic / other |
| Locations | 1 site (Ankara, Çankaya) |
| Status | Recruiting |
| Started | December 16, 2025 |
| Main results expected | February 16, 2026 |
| Study ends | February 16, 2026 |
| Registry record updated | January 8, 2026 |
| Trial ID | NCT07326293 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 65 years or older with ASA physical status I–III who are scheduled for elective oncologic surgery and can undergo standard anesthesia monitoring.
✕Probably not a fit
Patients with advanced coronary artery disease, severe heart failure or valvular disease, carotid stenosis, left ventricular ejection fraction <30%, rapid atrial fibrillation, BMI >35 kg/m², anticipated difficult airway, advanced-stage malignancy, or dementia were excluded and are unlikely to benefit from this protocol's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study of patients aged 65 and older scheduled for elective oncologic surgery at Ankara Bilkent City Hospital. During anesthesia induction and tracheal intubation, patients will have standard monitoring plus Masimo Rainbow SET pulse CO-oximetry to record Oxygen Reserve Index (ORI) and pulse oximetry (SpO2). Tolerable apnea time is defined as the interval from the end of ventilation after intubation until SpO2 falls to 94%; ORI alarm/warning times, arterial blood gas values at predefined time points, and Clinical Frailty Scale scores will be recorded. The primary analysis will examine the association between ORI warning time and tolerable apnea time, with secondary analyses correlating ORI values to ABG parameters and frailty.
Why it matters
Potential benefit: If ORI reliably signals declining oxygen reserves earlier than pulse oximetry, clinicians may be able to intervene sooner and reduce episodes of hypoxia during airway management in older surgical patients.
How similar studies have gone: Previous pilot and observational work has suggested ORI can provide earlier warning of falling oxygenation than SpO2 in other populations, but data specifically in geriatric oncologic surgery are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria for the files/records/materials to be included in the study: Records of patients aged 65 years and older, classified as ASA physical status I-III, who are scheduled for elective oncologic surgery. Exclusion criteria for the files/records/materials to be included in the study: Records of patients with advanced coronary artery disease; advanced heart failure and/or valvular heart disease; carotid artery stenosis; left ventricular ejection fraction below 30%; rapid atrial fibrillation; body mass index (BMI) greater than 35 kg/m²; anticipated difficult airway; advanced-stage malignancy; or dementia.
Where it's running
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Ankara Bilkent City Hospital
Ankara, Çankaya, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Muhlis Kuru
- Email: muhlis_kuru@hotmail.com
- Phone: +905312089322
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.