Overcoming Barriers to Focused Brain Stimulation with Transcranial Temporal Interference

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Transcranial temporal interference stimulation (TIS) uses two high-frequency currents to create a low-frequency beat that can target deep brain areas with improved focality. In healthy adults, researchers will apply TIS to the motor cortex and use established transcranial magnetic stimulation (TMS) to measure cortical excitability in relation to the TIS waveform phase. The goal is to determine whether observed effects are driven by the beat frequency and to characterize safety and tolerability in humans. This work builds on preclinical and early human data suggesting TIS may offer targeted neuromodulation with fewer invasions than implanted devices. The study is non-invasive and focused on understanding mechanisms and feasibility rather than therapeutic outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Free of neurological or orthopedic conditions that may impact the ability to participate.
* Right-hand dominant (self-reported)
* Aged 18-65 years

Exclusion Criteria:

* Ferromagnetic metal implants in the brain/skull or elsewhere (dental implants excluded).
* Any implanted electronic device (e.g. cardiac pacemaker, cochlear implant, deep brain stimulator, medication infusion pump; vagal nerve stimulator)
* Diseased or damaged skin on face or scalp
* History of migraines, fainting, seizures/epilepsy, or psychiatric illness
* Neurological disorder or intracranial lesion
* Frequent or severe headaches
* Prior adverse reaction to transcranial magnetic stimulation
* Currently pregnant
* Suspected or diagnosed heart problems (e.g. arrhythmia, cardiac disturbances).
* Insulin-dependent diabetes
* Suspected or diagnosed epilepsy or a familial history of epilepsy
* Use of alcohol or recreational drugs in the prior 12 hours
* Use of prescription and over the counter medications will be grounds for exclusion except for: contraceptive (birth control) drugs (e.g. those containing ethinyl estradiol and/or norethindrone), and seasonal allergy medications (e.g. cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin)).

Where it's running

• Northeastern University
  Boston, Massachusetts, United States Recruiting

Study contacts

• Principal investigator: Mathew Yarossi, PhD — Northeastern University
• Study coordinator: Joanne Hall, M.Sc.
• Email: hall.joa@northeastern.edu
• Phone: 17027828483

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How age affects germinal center responses after flu and rabies vaccines

  Researchers will test how the immune system responds to flu and rabies vaccines in younger adults (18–40) and older adults (65+).

  Recruiting Phase 4 Washington University School of Medicine · St Louis, Missouri · NCT07914673

• Magnetic field maps with NV sensors for non-invasive heart measurements

  This study tests whether diamond-based NV magnetometers can non-invasively detect and map the heart's magnetic field in healthy adults.

  Recruiting Robert Bosch GmbH · Renningen · NCT07908173

• Methylation analyses using home-based self-sampling in women with and without gynecological disease

  This study tests whether self-collected urine and vaginal samples can reveal DNA methylation markers that distinguish people with gynecological (pre-)cancers from cancer-free controls.

  Recruiting Universiteit Antwerpen · Edegem, Antwerp · NCT07902388

• Omega-3 status in healthy adults: comparing different fish-oil and algae-oil products

  This study tests whether various fish-oil and algae-oil products can raise the Omega-3 Index in healthy adults who don’t eat much fatty fish.

  Recruiting Nordic Naturals · London, Ontario · NCT07900425

• A safe, carefully dosed test of TBD11 in healthy adults

  This phase 1 study tests TBD11 in healthy adults to see if it is safe and tolerable and to understand how it behaves in the body, including how it interacts with other medicines.

  Recruiting Phase 1 Gates Medical Research Institute · Bloemfontein · NCT07883226

• Fosmanogepix in healthy adults: how it may interact with other drugs and heart rhythm

  This study tests whether fosmanogepix (and its active form manogepix) changes how other medicines work in healthy adults.

  Recruiting Phase 1 Basilea Pharmaceutica · Groningen, Netherlands · NCT07881224

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.