Outcomes after removing spinal cord gliomas through the dorsolateral sulcus approach

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, registry-based cohort compares clinical outcomes after intramedullary spinal cord glioma resection performed via the dorsolateral sulcus (DLS) approach versus the posterior median sulcus (PMS) approach. Eligible patients are aged 3–75 with histologically confirmed lateralized spinal cord gliomas and available clinical data for follow-up. Outcomes include pain (VAS), neurological function (McCormick grading and JOA score), SF-36 quality of life, and posterior column functional measures collected preoperatively and at scheduled postoperative time points. The registry will use validated clinical scales to compare postoperative function, complications, and quality-of-life trajectories between the two surgical routes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 3 and 75 years
2. Undergoing surgical resection of spinal cord tumor
3. Histopathological diagnosis of spinal cord glioma based on routine pathological examination
4. Availability of complete clinical data and willingness to participate in follow-up
5. Informed consent obtained from the patient and/or legal guardians or immediate family members

Exclusion Criteria:

1. Age under 3 years or over 75 years
2. Receipt of radiotherapy, chemotherapy, or anti-tumor biological therapy within 1 month prior to enrollment
3. Receipt of immunotherapy within 3 months prior to enrollment
4. Participation in other clinical trials within 3 months prior to enrollment
5. History of severe allergic reactions or known allergy-prone constitution
6. Pregnant or breastfeeding women, or individuals of childbearing potential not using adequate contraception
7. Presence of other severe medical conditions or uncontrolled infections
8. History of drug abuse, substance misuse, chronic alcoholism, or HIV infection
9. Uncontrolled epileptic seizures or psychiatric disorders resulting in loss of self-control

Where it's running

• Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Wang Yongzhi Wang, MD
• Email: yongzhiwang_bni@163.com
• Phone: +86 13466391736

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.