Outcomes after non-curative endoscopic removal of early colorectal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter observational study will enroll adults who had endoscopic resection for early colorectal cancer but whose pathology indicates a non-curative result, and will follow patients managed with either additional surgery or surveillance according to real-world clinical decisions. Investigators will collect baseline demographic, endoscopic, and pathological data and record treatments and outcomes across participating centers. The primary comparison is recurrence and survival between management strategies, while secondary aims include identifying prognostic factors and building a risk stratification model to guide individualized decisions. Standardized follow-up per clinical guidelines will be used to capture recurrence, complications, and survival outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years;
* Patients with early colorectal cancer confirmed by histopathology;
* Patients who underwent endoscopic resection (including EMR, ESD, or equivalent techniques);
* Pathological diagnosis indicating non-curative resection, defined by the presence of at least one of the following: positive resection margin, submucosal invasion depth \>1000 μm, poor differentiation, lymphovascular invasion, perineural invasion, or high-grade tumor budding;
* Availability of complete clinicopathological and follow-up data;
* Patients managed with either additional surgery or surveillance after endoscopic resection.

Exclusion Criteria:

* Patients with synchronous advanced colorectal cancer or distant metastasis at baseline;
* History of other active malignancies;
* Patients with inflammatory bowel disease, familial adenomatous polyposis, or other hereditary colorectal cancer syndromes;
* Patients who received neoadjuvant therapy before endoscopic resection;
* Incomplete pathological data or missing key variables;
* Loss to follow-up or follow-up duration less than 6 months.

Where it's running

• Nanfang Hospital, Southern Medical University
  Guangzhou, Guangdong, China Recruiting
• Shenzhen Longgang District People's Hospital
  Shenzhen, Guangdong, China Recruiting
• The Second Affiliated Hospital of Guangzhou Medical University
  Haizhu, Guangzhou, China Recruiting

Study contacts

• Study coordinator: Aimin Li
• Email: lam0725@163.com
• Phone: 86-13580317630

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.