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Clinical trial Recruiting at 1 site Observational Ages 40 to 85 Men only

Outcomes after focal cryotherapy for localized prostate cancer

Official title: Prospective Database of Clinical Outcomes Following Cryotherapy for Ablation of Clinically Localized Prostate Cancer

Run by NYU Langone Health · NCT07184957 · Data updated 2026-11-12

This project collects information from men with localized prostate cancer who choose focal cryotherapy to see how well the treatment controls disease and what side effects occur.

Quick facts

Study typeObservational
Ages40 Years to 85 Years
SexMen only
Enrollment1000 (estimated)
SponsorNYU Langone Health
Academic / other
Locations1 site (New York, New York)
StatusRecruiting
StartedMay 1, 2017
Main results expectedDecember 31, 2030
Study endsDecember 31, 2040
Registry record updatedAugust 7, 2026
Trial IDNCT07184957 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Men with clinically localized prostate cancer confined to the prostate on MRI and biopsy who choose focal cryoablation are the intended participants.

Probably not a fit

Men without prostate cancer, those with evidence of metastatic disease, or those who choose other treatments will not be included and are unlikely to benefit from this database.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective database will record baseline clinical, imaging, and biopsy information and then track treatment outcomes for men undergoing focal cryoablation of clinically localized prostate cancer at NYU Langone. Men whose cancer appears confined to the prostate by MRI and biopsy who elect focal cryotherapy are invited to enroll. Investigators will collect standardized follow‑up data on PSA, imaging, biopsy results when performed, and complications without changing patients' chosen treatments. The compiled data will be used to describe real-world oncologic and functional outcomes and to inform patient counseling and selection.

Why it matters

Potential benefit: If successful, the database could help doctors and patients understand real-world cancer control rates and side-effect risks after focal cryotherapy.

How similar studies have gone: Small series and registries have reported acceptable local control with cryotherapy in selected patients, but high-quality comparative data for focal cryoablation remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Evidence of focal prostate cancer confined to the prostate based on MRI imaging and prostate biopsy
* Patients with clinically localized prostate cancer (no evidence for or concern for metastatic spread of cancer outside of the prostate) will be counseled regarding treatment options. Those selecting focal Cryo prostate ablation will then be offered inclusion into this data collection.

Exclusion Criteria:

* Men that are not diagnosed with prostate cancer.
* Men that are diagnosed with clinically localized prostate cancer, but select other treatment options as their desired treatment.

Where it's running

  • NYU Langone Health
    New York, New York, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.