Osimertinib to slow growth of remaining ground-glass nodules after lung cancer surgery

A Phase II, Study of Osimertinib to Suppress the Progression of Remaining Ground-glass Opacity Nodule (GGN) in Other Lobes After Curative Resection for Actionable EGFR Mutation-positive Stage IB-IIIA Lung Adenocarcinoma

This will try daily oral osimertinib (80 mg) to slow or stop growth of persistent ground-glass nodules in adults who had surgery for stage I lung adenocarcinoma with an L858R or exon 19 EGFR mutation.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 43 (estimated)
• Ages: 30 Years to 75 Years
• Sex: All
• Sponsor: Samsung Medical Center (Academic / other)
• Drugs / interventions: osimertinib, chemotherapy, radiation
• Locations: 2 sites (Seoul, Kangnamgu and 1 other locations)
• Trial ID: NCT04591002 on ClinicalTrials.gov

What this trial studies

This Phase 2 study gives osimertinib 80 mg orally once daily to patients who have had curative resection for stage I lung adenocarcinoma with an actionable EGFR mutation (L858R or exon 19 deletion) and who have persistent ground-glass nodules (GGNs) in other lobes. Eligible GGNs are defined by radiologic criteria (well-defined margin, mean density above -500 HU, and diameter greater than 7.5 mm). Participants must be 30–75 years old, have WHO performance status 0–1, and show uneventful recovery from surgery. Patients will take osimertinib and be monitored for GGN progression and treatment tolerability.

Who should consider this trial

Good fit: Adults aged 30–75 who recovered uneventfully after curative-intent resection for stage I lung adenocarcinoma with an L858R or exon 19 EGFR mutation and who have persistent GGNs >7.5 mm in at least one other lobe with WHO performance status 0–1.

Not a fit: Patients without the specified EGFR mutations (L858R or exon 19 deletion), with GGNs below the size/density criteria, with advanced disease or poor performance status, or with unresolved postoperative complications are unlikely to benefit from this approach.

Why it matters

Potential benefit: If successful, osimertinib could slow or stop growth of residual GGNs and reduce the need for additional surgery or progression to advanced disease.

How similar studies have performed: Osimertinib has shown substantial disease-free survival benefit as adjuvant therapy in EGFR-mutant resected NSCLC (for example, ADAURA), but its specific use to suppress or shrink persistent GGNs is less well studied and remains relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Provision of informed consent prior to any study specific procedures
2. Adult male or female patients, aged from 30 to 75 years
3. Pathologic proven stage I lung adenocarcinoma with additional persistent GGNs in at least one other lobe: GGN is defined as a ground glass-opacity with well-defined margin, mean density above -500 HU and greater than 7.5 mm in its maximum diameter
4. The resected lung adenocarcinoma should have actionable EGFR mutation, which is limited to L858R or exon 19 deletion.
5. WHO performance status 0-1 with no deterioration over the previous 2 weeks and a minimum life expectancy of 12 weeks
6. Uneventful recovery from curative-intent lung cancer surgery
7. Female subjects should be using highly effective contraceptive measures, and must have a negative pregnancy test and not be breast-feeding prior to start of dosing if of childbearing potential or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:

   * Post-menopausal defined as aged more than 50 years and amenorrheic for at least 12 months following cessation of all exogenous hormonal treatments
   * Women under 50 years old would be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and with LH and FSH levels in the post-menopausal range for the institution
   * Documentation of irreversible surgical sterilisation by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation Further information in Appendix E (Definition of Women of Childbearing Potential and Acceptable Contraceptive Methods)
8. Male subjects should be willing to use barrier contraception (see Restrictions, Section 3.8)

Exclusion Criteria:

1. Treatment with any neoadjuvant therapy (radiation, any cytotoxic chemotherapy, investigational agents or other anticancer drugs after surgery) before randomization
2. Treatment with any adjuvant therapy (any cytotoxic chemotherapy, investigational agents or other anticancer drugs after surgery) before randomization
3. Extensive surgery other than lobectomy or sublobar resection (i.e. bilobectomy, sleeve lobectomy, pneumonectomy)
4. Past history of postoperative ALI/ARDS or pneumonia during recovery period
5. Currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4 (at least 3 week prior) (Appendix C). All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foodswith known inducer effects on CYP3A4.
6. Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator's opinion makes it undesirable for the patient to participate in the trial or which would jeopardise compliance with the protocol, or active infection including hepatitis B, hepatitis and human immunodeficiency virus (HIV). Screening for chronic conditions is not required.
7. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of osimertinib.
8. Any of the following cardiac criteria:

   * Mean resting corrected QT interval (QTc) \> 470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc value. Whenever QTc, is mentioned in this document, this refers to correction e made by Fridericia formula (QTcF),
   * Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g. complete left bundle branch block, third degree heart block and second degree heart block.
   * Patient with any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: Serum/plasma potassium \< LLN; Serum/plasma magnesium \< LLN; Serum/plasma calcium \< LLN) , congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval and cause Torsades de Pointes
9. Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease.
10. Inadequate bone marrow reserve or organ function (as demonstrated by any of the following laboratory values:

    * Absolute neutrophil count \<1.5 x 109/L;
    * Platelet count \<100 x 109/L;
    * Haemoglobin \<90 g/L;
    * Alanine aminotransferase \>2.5 times ULN if no demonstrable liver metastases or \>5 times ULN in the presence of liver metastases;
    * Aspartate aminotransferase \>2.5 times ULN if no demonstrable liver metastases or \>5 times ULN in the presence of liver metastases;
    * Total bilirubin \>1.5 times ULN if no liver metastases or \>3 times ULN in the presence of documented Gilbert's Syndrome \[unconjugated hyperbilirubinaemia\] or liver metastases;
    * Serum creatinine \>1.5 times ULN concurrent with creatinine clearance \<50 mL/min \[measured or calculated by Cockcroft and Gault equation\]-confirmation of creatinine clearance is only required when creatinine is \>1.5 times ULN.
11. Women who are breast-feeding.
12. Males and females of reproductive potential who are not using and effective method of birth control and females who are pregnant or breastfeeding or have a positive (urine or serum) pregnancy test prior to study entry.
13. Involvement in the planning and conduct of the study (applies to AstraZeneca staff or staff at the study site).
14. Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements.

Where this trial is running

Seoul, Kangnamgu and 1 other locations

• Smc — Seoul, Kangnamgu, South Korea (Recruiting)
• Samsung medical center — Seoul, South Korea (Suspended)

Study contacts

• Study coordinator: Sehoon Lee, MD

Conditions Lung Cancer