Oscillation plus lung-expansion therapy to clear mucus and reopen lungs in ventilated patients with atelectasis
Official title: The Efficacy of Oscillation and Lung Expansion (OLE) Therapy Evaluated by Compterized Tomography (CT) and Electrical Impedance Tomography（EIT）in Prolonged Mechanical Ventilated Patients With Atelectasis: A Multicenter Randomized Contralled Trial
Run by Capital Medical University · NCT07451405 · Data updated 2026-11-12
This trial tests whether combining chest oscillation with continuous positive airway pressure and high-frequency oscillation can help adults on prolonged mechanical ventilation with atelectasis clear mucus and re-expand their lungs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Capital Medical University Academic / other |
| Locations | 2 sites (Beijing, Beijing Municipality and 1 other locations) |
| Status | Recruiting |
| Started | March 15, 2026 |
| Main results expected | April 1, 2026 |
| Study ends | October 1, 2026 |
| Registry record updated | March 5, 2026 |
| Trial ID | NCT07451405 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with prolonged tracheostomy (≥7 days), frequent heavy airway secretions related to pulmonary infection, and stable vital signs are the intended participants.
✕Probably not a fit
Patients who are hemodynamically unstable, have untreated pneumothorax, very high oxygen requirements (FiO2 > 60%), recent total pneumonectomy, active hemoptysis, pulmonary bullae, delirium, or who cannot tolerate chest oscillation are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study compares a combined oscillation and lung-expansion (OLE) approach—which integrates CPAP, continuous high-frequency oscillation, and external chest oscillation—against high-frequency chest wall oscillation or other standard airway clearance therapies in hospitalized patients. Eligible patients are adults with prolonged tracheostomy (≥7 days) who have frequent, heavy airway secretions and stable vital signs. Outcomes include secretion clearance, lung re-expansion assessed by imaging and electrical impedance tomography, and changes in respiratory parameters and oxygenation. Safety, tolerance, and short-term clinical respiratory outcomes will be monitored during treatment at the respiratory rehabilitation center.
Why it matters
Potential benefit: If successful, OLE could speed mucus clearance and reopen collapsed lung areas, potentially shortening time on the ventilator and improving breathing.
How similar studies have gone: High-frequency chest wall oscillation has prior clinical support for improving secretion clearance, but the combined OLE approach (CPAP plus continuous high-frequency oscillation) is a newer, less-tested integrated technique.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years old * The following characteristics of high mucus secretion in the airway occur along with pulmonary infection: coughing up a large amount of white sticky phlegm, yellow phlegm or yellow purulent phlegm; Phlegm sounds can be heard in the lungs. The frequency of sputum aspiration is higher than once every 4 hours * Tracheotomy time ≥7 days * Vital signs are stable. Exclusion Criteria: * Hemodynamic instability * Inhaled oxygen concentration (FiO2) \> 60% * Untreated pneumothorax * Patients who have undergone total pneumonectomy * Hemoptysis * Pulmonary bullae, etc. * Patients with delirium and restlessness
Where it's running
-
Respiratory rehabilitation center
Beijing, Beijing Municipality, China Recruiting -
Shuo Chen
Beijing, China Completed
Study contacts
- Study coordinator: Shuo Chen
- Email: 983340122@qq.com
- Phone: +86 13521362894
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.