Oral treatment with AZD4205 for patients with relapsed or refractory Peripheral T Cell Lymphoma

A Phase II, Open-Label, Single-Arm Study to Investigate the Safety, Tolerability, and Anti-tumor Activity of AZD4205 Treating Relapsed or Refractory Peripheral T Cell Lymphoma (r/r PTCL)

This study is testing a new oral medication called AZD4205 to see if it can help people with relapsed or hard-to-treat Peripheral T Cell Lymphoma feel better.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 150 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Dizal Pharmaceuticals (Industry-sponsored)
• Drugs / interventions: brentuximab, chemotherapy, immunotherapy, radiation, prednisone
• Locations: 19 sites (Hefei, Anhui and 18 other locations)
• Trial ID: NCT06511895 on ClinicalTrials.gov

What this trial studies

This phase II, open-label, multicenter study evaluates the safety, tolerability, pharmacokinetics, and anti-tumor activity of AZD4205 in patients with relapsed or refractory Peripheral T Cell Lymphoma (PTCL). Participants must have pathologically confirmed PTCL and have experienced relapse or refractory disease after at least one prior systemic treatment. The primary focus is to assess the anti-tumor efficacy of AZD4205 administered at a dose of 150 mg once daily. The study aims to provide insights into the drug's effectiveness and safety profile in this patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older with confirmed relapsed or refractory PTCL who have not responded to or are intolerant to previous treatments.

Not a fit: Patients with PTCL who are not relapsed or refractory, or those who are transplant-eligible, may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could offer a new therapeutic option for patients with difficult-to-treat relapsed or refractory PTCL.

How similar studies have performed: While this approach is being tested in this specific context, similar studies have shown promise in targeting relapsed or refractory lymphomas with novel therapies.

Eligibility criteria

Inclusion criteria:

1. ≥ 18 years old (for Korean ≥ 19 years old)
2. ECOG performance status 0-2 with no deterioration over the previous 2 weeks
3. Predicted life expectancy ≥ 12 weeks.
4. Histologically confirmed PTCL by local pathology review according to the 2016 revision of the WHO classification of lymphoid neoplasms. Eligible histological subtypes are restricted to the following:

   * PTCL-NOS
   * AITL
   * ALCL ALK+
   * ALCL ALK-
   * EATL
   * MEITL
   * NKTCL
   * HSTCL
   * SPTCL
5. Have measurable disease according to the 2014 Lugano classification
6. Must have progressed on or are refractory to standard systemic therapy, or patients were intolerant to standard systemic therapy. Participants should be transplant-ineligible upon their entries to this study.
7. Adequate bone marrow reserve and organ system functions
8. LVEF ≥ 55% assessed by ECHO or MUGA.
9. Male participant with female partners of child-bearing potential should be willing to use barrier contraceptives (i.e., by use of condoms), during his participation in this study and for 6 months following the last dose of the study drug. Male participant must refrain from donating sperm during their participation in the study and at least for 6 months after the last treatment.
10. Female participant should be using adequate contraceptive measures while on study drug and for 3 months following the last dose of study drug.

Exclusion criteria:

1. Intervention with any of the following:

   * Any investigational agents or study drugs from a previous clinical study within 30 days of the first dose of study treatment.
   * Any cytotoxic chemotherapy from a previous treatment regimen within 21 days of the first dose of study treatment.
   * Prior HDAC inhibitors (including romidepsin, belinostat and chidamide) or pralatrexate therapy within one week of the start of the study treatment.
   * Corticosteroids at dosages equivalent to prednisone \> 15 mg/day within 7 days of the start of the study treatment.
   * Major surgery procedure (excluding placement of vascular access), or significant traumatic injury within 4 weeks of the first dose of study treatment, or have an anticipated need for major surgery during the study.
   * Prior therapeutic anticancer antibodies (including brentuximab vedotin) within 4 weeks, other radio- or toxin-immunoconjugates within 10 weeks, radiation therapy within 3 weeks.
   * Has undergone an allogeneic stem cell transplant. Participant had autologous stem cell transplant within 6 months.
   * Prior treatment with a JAK or STAT3 inhibitor.
   * Prior treatment with any onco-immunotherapy in 28 days prior to first dosing of AZD4205.
   * Live vaccines within 28 days prior to first dose.
   * Currently receiving (or unable to stop use at least 1 week prior to receiving the first dose) vitamin K antagonists, anti-platelet agents or anticoagulated agents.
   * Currently receiving (or unable to stop use at least 1 week prior to receiving the first dose) medications or herbal supplements known to be potent inhibitors or inducers of CYP3A or sensitive substrates of BCRP or P-gp with narrow therapeutic index.
2. Any unresolved toxicities from prior therapy, greater than CTCAE v 5.0 Grade 1 at the time of starting study treatment with the exception of alopecia.
3. Central nervous system or leptomeningeal lymphoma.
4. With severely decreased lung function (i.e. any parameter of FEV1, and DLCO \< 60% of predicted value). Past medical history of pneumonitis, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease.
5. With disease condition which requires the treatment of immunosuppressants, biologics, or NSAIDs (non-steroid anti-inflammatory drugs).
6. Active infections including:

   * History of known latent or active tuberculosis (TB).
   * Known infection with HIV, or serologic status reflecting active hepatitis B or hepatitis C infection.
   * Active viral infections (i.e. zoster) other than hepatitis B or C.
   * Infections requiring oral or intravenous antimicrobial therapy or interferon.
   * Bacterial infections including pneumonia within 30 days.
7. Any of the following cardiac criteria:

   * Congestive heart failure (CHF) per NYHA classification \> Class II.
   * Clinically significant valvular diseases, hypertrophic or constrictive cardiomyopathy.
   * Any clinically significant abnormalities in rhythm, conduction or morphology of resting ECG, e.g., complete left bundle branch block, third degree heart block, and second-degree heart block, PR interval \> 250 msec.
   * Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy.
   * AMI within 6 months prior to starting treatment, unstable angina or new-onset angina.
   * With heart transplant.
   * Mean resting corrected QTcF interval (QTC) \> 450 ms on ECG.
   * With factors that increase the risk of QT prolongation or arrhythmic events (e.g., heart failure, hypokalaemia, congenital long QT syndrome, any concomitant medication known to prolong the QT interval) or family history of long QT interval syndrome or unexplained sudden death under 40 years of age in first degree relatives.
   * With previous/current thrombotic diseases such as pulmonary embolism, and deep venous thrombosis.
8. Another malignancy within 5 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell carcinoma or non-melanomatous skin cancer.

Where this trial is running

Hefei, Anhui and 18 other locations

• Anhui Provincial Hospital (The First Affiliated Hospital of USTC) — Hefei, Anhui, China (Recruiting)
• The Second Hospital of Anhui Meidcine University — Hefei, Anhui, China (Recruiting)
• Beijing Cancer Hospital — Beijing, Beijing, China (Recruiting)
• Peking University Third Hospital — Beijing, Beijing, China (Recruiting)
• Chongqing Cancer Hospital — Chongqing, Chongqing, China (Recruiting)
• Guangdong Provincial People's Hospital — Guangzhou, Guangdong, China (Recruiting)
• Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China (Recruiting)
• Hainan General Hospital — Haikou, Hainan, China (Recruiting)
• Henan Cancer Hospital — Zhengzhou, Henan, China (Recruiting)
• Union Hospital Tongji Medical College Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
• Hunan Cancer Hospital — Changsha, Hunan, China (Recruiting)
• Jiangsu Cancer Hospital — Nanjing, Jiangsu, China (Recruiting)
• The First Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China (Recruiting)
• The First Bethune Hospital of Jilin University — Changchun, Jilin, China (Recruiting)
• Shandong Cancer Hospital & Insititution — Jinan, Shandong, China (Recruiting)
• Ruijing Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai, China (Recruiting)
• West China Hospital of Sichuan University — Chengdu, Sichuan, China (Recruiting)
• Tianjin Medical University Cancer Institute & Hospital — Tianjin, Tianjin, China (Recruiting)
• Zhejiang Cancer Hospital — Hangzhou, Zhejiang, China (Recruiting)

Study contacts

• Principal investigator: Yuqin Song — Peking University Cancer Hospital & Institute
• Study coordinator: Rika Chen

Conditions Peripheral T Cell Lymphoma