Oral tranexamic acid after total shoulder replacement to reduce bleeding and help early recovery.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 3 interventional study at the University of Alabama at Birmingham gives patients undergoing primary total shoulder arthroplasty an extended postoperative course of either oral tranexamic acid or a matching placebo. Participants are skeletally mature adults aged 18–79 and those with active cancer, prior venous thromboembolism or stroke, significant heart disease, pregnancy or nursing, TXA allergy, current tobacco use, or use of anticoagulants other than aspirin are excluded. The trial focuses on short-term postoperative clinical outcomes, including measures related to bleeding, hemoglobin, wound complications, and early functional recovery. Results will show whether an extended oral TXA regimen improves early recovery after shoulder replacement compared with placebo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Skeletally mature patients (ages 18-79) undergoing primary total shoulder arthroplasty

Exclusion Criteria:

* Patients with Cancer, venous thromboembolism, stroke, heart disease, pregnant or nursing, allergic to TXA, current tobacco use, anticoagulants other than aspirin.

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Walter Smith, MD — University of Alabama at Birmingham
• Study coordinator: Walter Smith
• Email: waltersmith@uabmc.edu
• Phone: 205-930-8554

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.