Oral mucosa versus labial grafts for female urethral reconstruction
Official title: Oral Mucosal Graft Versus Labial Graft in Female Urethroplasty: A Prospective Comparative Study
Run by Tanta University · NCT07153861 · Data updated 2026-11-12
This trial will see if oral mucosal grafts or labial grafts work better for women having urethroplasty to treat urethral stricture.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 40 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Status | Recruiting |
| Started | February 26, 2025 |
| Main results expected | January 1, 2026 |
| Study ends | January 1, 2026 |
| Registry record updated | September 4, 2025 |
| Trial ID | NCT07153861 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women with non‑traumatic urethral stricture who are candidates for urethral reconstruction and have no systemic contraindications to surgery.
✕Probably not a fit
Women with traumatic urethral strictures or with systemic surgical contraindications such as bleeding disorders would not be expected to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Female urethral stricture is an uncommon cause of bladder outlet obstruction and may require urethral reconstruction when minimally invasive procedures fail. This interventional study directly compares augmentation urethroplasty using oral mucosal grafts versus labial grafts in women with non‑traumatic urethral strictures. Eligible participants will undergo one of the two graft procedures and be followed for surgical outcomes, complications, and recurrence. The trial is conducted as a single‑center study at Tanta University in Egypt with standard perioperative and follow‑up care.
Why it matters
Potential benefit: If successful, the comparison could identify a graft type that lowers recurrence and improves urinary function after urethroplasty in women.
How similar studies have gone: Oral mucosal grafts, especially buccal mucosa, have been widely reported with good outcomes in urethroplasty, while labial/vaginal grafts have smaller series and less comparative data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients with urethral stricture. * Female patients with non-traumatic urethral stricture. Exclusion Criteria: * Female patients with traumatic urethral stricture. * Female patients with systemic contraindications of surgery like bleeding disorders.
Where it's running
-
Tanta University
Tanta, El-Gharbia, Egypt Recruiting
Study contacts
- Study coordinator: Elmaadawy I Elmaadawy, MD
- Email: Mohamed.elmaadawy@med.tanta.edu.eg
- Phone: 00201060245430
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.