Oral mucosa versus labial grafts for female urethral reconstruction
Oral Mucosal Graft Versus Labial Graft in Female Urethroplasty: A Prospective Comparative Study
This trial will see if oral mucosal grafts or labial grafts work better for women having urethroplasty to treat urethral stricture.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT07153861 on ClinicalTrials.gov |
What this trial studies
Female urethral stricture is an uncommon cause of bladder outlet obstruction and may require urethral reconstruction when minimally invasive procedures fail. This interventional study directly compares augmentation urethroplasty using oral mucosal grafts versus labial grafts in women with non‑traumatic urethral strictures. Eligible participants will undergo one of the two graft procedures and be followed for surgical outcomes, complications, and recurrence. The trial is conducted as a single‑center study at Tanta University in Egypt with standard perioperative and follow‑up care.
Who should consider this trial
Good fit: Women with non‑traumatic urethral stricture who are candidates for urethral reconstruction and have no systemic contraindications to surgery.
Not a fit: Women with traumatic urethral strictures or with systemic surgical contraindications such as bleeding disorders would not be expected to benefit or be eligible.
Why it matters
Potential benefit: If successful, the comparison could identify a graft type that lowers recurrence and improves urinary function after urethroplasty in women.
How similar studies have performed: Oral mucosal grafts, especially buccal mucosa, have been widely reported with good outcomes in urethroplasty, while labial/vaginal grafts have smaller series and less comparative data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients with urethral stricture. * Female patients with non-traumatic urethral stricture. Exclusion Criteria: * Female patients with traumatic urethral stricture. * Female patients with systemic contraindications of surgery like bleeding disorders.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (Recruiting)
Study contacts
- Study coordinator: Elmaadawy I Elmaadawy, MD
- Email: Mohamed.elmaadawy@med.tanta.edu.eg
- Phone: 00201060245430
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.