Oral immunotherapy for children with egg allergy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of a 12-month oral immunotherapy (OIT) protocol using a cooked whole egg product, which includes both yolk and egg white, for children aged 6 to 16 with egg allergies. The researchers hypothesize that this method will reduce the risk of severe allergic reactions and may allow for a normalized diet. The study will also investigate the immune responses to the whole egg OIT and compare its efficacy and side effects in children with and without asthma. By using a whole egg product, the study seeks to provide a more natural and cost-effective approach to treating egg allergies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 6 to 16 years
* Elevated spesific serum IgE to egg (\> 5 kU/l) and/or positive skin prick to egg allergen
* Positive oral food challenge for egg or anaphylaxis reaction to egg within the 6 months
* Diet free from egg in any form

Exclusion Criteria:

* Age less than 6 years or more than 16 years
* Poor asthma control or uncontrolled asthma
* Severe/significant cardiovascular disease
* Autoimmune disease
* Malignancy
* Medication: beta bloker, angiotensin-converting-enzyme inhibitors (ACE inhibitors), Monoamine oxidase inhibitors (MAOIs)
* Poor compliance
* Fear of immunotherapy
* Desensitization to alfa-gal-protein (mammalian meat allergy)

Where it's running

• Oulu University Hospital
  Oulu, Finland Recruiting
• Tampere University Hospital
  Tampere, Finland Recruiting

Study contacts

• Principal investigator: Rüdiger Schultz, MD., PhD — Tampere University Hospital
• Study coordinator: Rüdiger Schultz, MD., PhD
• Email: rudiger.schultz58@gmail.com
• Phone: +358

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Remibrutinib for IgE-mediated peanut, milk, and egg allergy

  This study tests whether remibrutinib can help people with peanut, milk, or egg allergies by comparing it to placebo over 52 weeks.

  Recruiting at 22 sites Phase 3 Novartis · Birmingham, Alabama and 21 other locations · NCT07768371

• Long-term follow-up after 18 months of oral immunotherapy for peanut, egg, or milk allergy (5–15 years later)

  This follow-up will see if children and young people who completed an 18-month oral immunotherapy for peanut, egg, or milk allergy still have changes in allergy tests and better quality of life 5–15 years later.

  Recruiting Murdoch Childrens Research Institute · Parkville, Victoria · NCT07359183

• Rush versus conventional oral immunotherapy for cow's milk and hen's egg allergy in children

  This test compares a faster 'rush' oral immunotherapy schedule with a conventional slower schedule to see which better helps children aged 6–16 with milk or egg allergy tolerate those foods.

  Recruiting Phase 2/3 Fundación de Investigación Biomédica - Hospital Universitario de La Princesa · Madrid · NCT06976775

• Maternal peanut and egg consumption versus avoidance during pregnancy and breastfeeding

  This study will test whether mothers eating or avoiding peanuts and eggs from late pregnancy through breastfeeding changes babies' chances of developing peanut or egg allergies.

  Recruiting University of Rochester · Rochester, New York · NCT06260956

• Investigating new methods for oral immunotherapy in food allergies

  This study is testing new ways to use oral immunotherapy to help people with food allergies, like those to peanuts and milk, feel safer and have fewer allergic reactions during treatment.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT06256146

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.