Clinical trial Recruiting at 1 site Interventional Ages 18 to 80

Oral care program for patients with head and neck cancer

Official title: Evaluation of an Oral Care Programme for Patients Undergoing Treatment for Head and Neck Cancer Regarding Mucositis, Oral Health, Epigenetic Modifications, Patient-related Factors, Quality of Life and Health Economy

Run by Göteborg University · NCT03481647 · Data updated 2026-11-12

This study tests if a special oral care program can help people with head and neck cancer have less mouth soreness during their treatment compared to standard care.

Quick facts

Study typeInterventional
Ages18 Years to 80 Years
SexAll
Enrollment150 (estimated)
SponsorGöteborg University
Academic / other
Drugs / interventionsradiation
Locations2 sites (Gothenburg and 1 other locations)
StatusRecruiting
StartedJanuary 8, 2018
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedApril 20, 2025
Trial IDNCT03481647 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients scheduled to receive full-dose curative radiation therapy that includes major salivary glands in the radiation field.

Probably not a fit

Patients with recurrent cancer or severe cognitive impairment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact of an intensified oral care program on the prevalence, severity, and duration of mucositis in patients undergoing treatment for head and neck cancer. Participants will receive professional oral care and will be instructed to perform daily rinses with a saline/bicarbonate solution. The program includes weekly professional care and the use of an oral care diary to track hygiene practices. A control group will receive standard oral care once a week for comparison.

Why it matters

Potential benefit: If successful, this program could significantly reduce the incidence and severity of mucositis, improving the quality of life for head and neck cancer patients during treatment.

How similar studies have gone: Other studies have shown that improved oral care can positively impact mucositis in cancer patients, suggesting this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients scheduled to receive full dose of curative RT including major salivary glands in the radiation field

Exclusion Criteria:

* Patients with recurrent cancer
* Patients with severe cognitive impairment.

Where it's running

  • Länssjukhuset Ryhov
    Jönköping, Sweden
    Recruiting
  • Institute of odontology
    Gothenburg, Sweden
    Active not recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.