Oral antibiotics for treating bone and joint infections in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This nationwide, prospective, multicenter cohort study aims to evaluate the effectiveness and safety of initial oral antibiotic treatment for children and adolescents aged 3 months to 17 years with uncomplicated bone and joint infections. The study will compare real-world outcomes of these patients with those who received oral antibiotics in a previous randomized controlled trial. Conducted across 18 Pediatric Departments in Denmark, the study will include 100 participants treated with oral antibiotics from 2024 to 2026. The goal is to provide insights into the real-world application of oral antibiotics in this patient population.

Why it matters

Who can join: the full rules

Children and adolescents aged 3 months to 17 years with uncomplicated bone and joint infections treated with initial oral antibiotics.

According to Danish Nationwide Guidelines (initiated in 2024), initial oral antibiotics are recommended to patients with no risk factors for complicated disease. Risk factors include for complicated disease include:

1. Severe illness or sepsis
2. Rapid symptom progression
3. Pronounced symptoms, including severe pain
4. Pronounced soft tissue involvement
5. Foreign material or post-surgical infection
6. Infection with a resistent or rare pathogen, e.g., Salmonella or MRSA
7. Severe comorbidity, including immunodeficiency

Patients who have received intravenous antibiotic therapy for less than 24 h before oral antibiotics will be included

Where it's running

• Rigshospitalet
  Copenhagen Ø, Denmark Recruiting

Study contacts

• Study coordinator: Ulrikka Nygaard, Ass Professor, PhD, MD, MPhil
• Email: Ulrikka.Nygaard@regionh.dk
• Phone: +45 35459761

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Oral antibiotics for treating bone and joint infections in children

  This study tests if giving only oral antibiotics can effectively treat bone and joint infections in children, compared to the usual method that starts with IV antibiotics.

  Recruiting at 9 sites Phase 4 Murdoch Childrens Research Institute · Kingswood, New South Wales and 10 other locations · NCT04538053

• Trimethoprim-sulfamethoxazole versus clindamycin for children with invasive MRSA infections

  This will see if trimethoprim-sulfamethoxazole works as well as clindamycin to treat invasive MRSA infections in children aged 60 days to 18 years.

  Recruiting Phase 4 Indiana University · Indianapolis, Indiana · NCT06982105

• Using alpha-defensin and synovial proteins to diagnose pediatric septic arthritis

  This study is testing if certain proteins in joint fluid can help doctors better diagnose septic arthritis in children who might have joint infections.

  Recruiting at 2 sites Hospital for Special Surgery, New York · Atlanta, Georgia and 2 other locations · NCT03704766

• High-resolution infrared imaging to detect bone, joint and soft-tissue infections in children

  We will test whether a 10-second high-resolution infrared thermal video can help detect bone, joint, or soft-tissue infections in children up to 15 years old.

  Recruiting Sheffield Children's NHS Foundation Trust · Sheffield, South Yorkshire · NCT07388017

• Ultralow-dose PET scan to detect bone activity with 18F‑NaF

  This trial tests whether a new high-sensitivity PET scan using a tiny amount of 18F‑sodium fluoride can produce clear bone images in adults with or without bone disease while cutting radiation exposure by 10–100 times.

  Recruiting Phase 2 Nuclear Imaging Institute · Englewood, New Jersey and 1 other locations · NCT07284563

• Comparing two types of spacers for treating knee joint infections

  This study is testing which type of spacer works better for treating knee joint infections in patients who have had knee replacement surgery.

  Recruiting Northwestern University · Chicago, Illinois · NCT06293352

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.