Optimizing treatment for heart attack using advanced techniques
Official title: The STEMI Optimization Trial - Ischemic Postconditioning (DANAMI4-iPOST) and Intravascular Ultrasound Guided PCI in STEMI (DANAMI4-iSTEMI)
Run by Copenhagen University Hospital, Rigshospitalet · NCT04775914 · Data updated 2026-11-12
This study is testing if a new way of treating heart attacks using special techniques can help people with severe chest pain recover better than the usual treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Locations | 1 site (Copenhagen, Capital Region) |
| Status | Recruiting |
| Started | April 1, 2021 |
| Main results expected | February 1, 2027 |
| Study ends | February 1, 2031 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT04775914 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who present with acute chest pain and meet specific criteria for STEMI.
✕Probably not a fit
Patients with a pre-PCI TIMI flow of 0 or 1, those who are pregnant, or individuals unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of ischemic postconditioning (iPOST) combined with intravascular ultrasound (IVUS) guidance during percutaneous coronary intervention (PCI) for patients experiencing ST-segment elevation myocardial infarction (STEMI). The goal is to determine if these advanced techniques can improve clinical outcomes compared to standard PCI methods. Patients with acute chest pain and specific ST elevation criteria will be enrolled, and their treatment will be closely monitored to assess the benefits of the intervention.
Why it matters
Potential benefit: If successful, this approach could lead to better recovery outcomes for patients suffering from heart attacks.
How similar studies have gone: While this approach is innovative, similar studies have shown promise in improving outcomes for heart attack patients using advanced PCI techniques.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Acute onset of chest pain with \<12 hours duration * STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI. Exclusion Criteria (iPOST2): Pre-PCI TIMI flow 0 or 1 Potential pregnancy Inability to provide informed consent Unwillingness to consent Unavoidable to use thrombectomy Spontaneous coronary artery dissection Time from symptoms onset to PPCI \> 12 hours Culprit in bypass graft Other reason for not including the patient Exclusion Criteria (iSTEMI): Potential pregnancy Inability to understand information in order to provide informed consent Unwillingness to consent Spontaneous coronary artery dissection Time from symptoms inset to PPCI \> 12 hours Culprit in bypass graft Other reason
Where it's running
-
Heart Center, Rigshospitalet
Copenhagen, Capital Region, Denmark Recruiting
Study contacts
- Study coordinator: Thomas Engstrøm, MD PhD DSci
- Email: Thomas.Engstroem@regionh.dk
- Phone: +45 3545 8444
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Smartphone AI help for prehospital ECG readings
This study tests whether using a smartphone AI (GPT-4o) to help prehospital providers read 12-lead ECGs improves accuracy in diagnosing acute coronary syndromes and related conditions.
-
Coronary thrombus modification to reduce microvascular damage during STEMI care
This study tests whether modifying the clot in the heart arteries during primary PCI can lessen microvascular damage and myocardial injury in STEMI patients.
-
Crystalline sirolimus-coated balloon for treating coronary artery disease
This tests whether a crystalline sirolimus-coated balloon is safe and effective for adults having percutaneous coronary intervention for coronary artery blockages or in-stent restenosis.
-
Drug-coated balloon treatment during emergency angioplasty for STEMI
This registry will try using drug-coated balloons instead of stents during emergency PCI for people with ST-elevation heart attacks to see how the procedure and patient outcomes compare.
-
Low-level tragus stimulation to improve heart function after ST-elevation heart attack
This trial will see if low-level tragus stimulation applied near the ear can improve heart pumping and wall motion on echocardiogram in people with ST-elevation heart attacks treated with primary PCI.
-
Measuring heart microvascular function in heart attack patients
This study is testing how well the tiny blood vessels in the heart work in people who have had a heart attack to see how treatment affects their recovery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.