Optimizing treatment for adhesive small bowel obstruction
The Use of Nasogastric Tubes And Water-Soluble Contrast In The Management Of Small Bowel Obstruction: A Feasibility Study
This study is testing whether using nasogastric tubes or water-soluble contrast can improve treatment for adults with adhesive small bowel obstruction and help them feel better.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT06182319 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to improve the treatment protocols for adhesive small bowel obstruction (aSBO), a common gastrointestinal issue. It will assess the feasibility of randomizing patients to receive either nasogastric tubes (NGTs) or water-soluble contrast (WSC) as part of their treatment. The study will also focus on measuring health-related quality of life (HRQOL) as a primary outcome, addressing critical gaps in understanding who benefits from NGT placement and how to manage feeding reintroduction. The trial will involve patients aged 18 and older who exhibit clinical features of aSBO.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with documented adhesive small bowel obstruction.
Not a fit: Patients with nonadhesive small bowel obstruction or those with certain serious medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and tailored treatment options for patients suffering from adhesive small bowel obstruction.
How similar studies have performed: Other studies have explored treatment protocols for bowel obstructions, but this specific approach to optimizing aSBO treatment is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Male or female ≥18 years of age. 2. Documentation of aSBO as evidenced by one or more clinical features meeting the following criteria: Nausea, emesis, abdominal pain, distended abdomen CT evidence of aSBO Exclusion Criteria: 1. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study. 2. Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data. 3. Unstable angina or recent myocardial infarction (MI)/stroke within 6 months 4. Nonadhesive SBO 1. Paralytic Ileus 2. Incarcerated hernia 3. Fecal impaction 4. Intra-abdominal malignancy Early aSBO within 4 weeks of a prior abdominal operation
Where this trial is running
Los Angeles, California
- University of California, Los Angeles, David Geffen School of Medicine — Los Angeles, California, United States (Recruiting)
Study contacts
- Study coordinator: Steven Stokes
- Email: sstokes@mednet.ucla.edu
- Phone: 310-206-7436
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.