Clinical trial Recruiting at 1 site Interventional Ages 50 and up

Optimizing PPI prescribing with EHR decision support

Official title: Quality Improvement Initiative Leveraging Electronic Healthcare Records to Reduce Inappropriate Proton Pump Inhibitors (PPI) Prescribing at UCLA.

Run by University of California, Los Angeles · NCT06998966 · Data updated 2026-11-12

This project tests whether changing EHR prescription defaults and adding active-choice prompts will reduce overprescribing of proton pump inhibitors by UCLA primary care physicians.

Quick facts

Study typeInterventional
Ages50 Years and up
SexAll
Enrollment372 (estimated)
SponsorUniversity of California, Los Angeles
Academic / other
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedJune 2026
Main results expectedApril 2027
Study endsJune 2027
Registry record updatedApril 29, 2026
Trial IDNCT06998966 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Primary care physicians at UCLA Health with a clinical full-time equivalency of at least 25% are the intended participants.

Probably not a fit

Patients with clear indications for long-term PPI therapy (for example, Barrett's esophagus, high-risk GI bleeding history, or other specialist-directed chronic use) may not experience reduced prescriptions from default changes.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The initiative implements alternative order-panel configurations in UCLA's CareConnect EHR, including indication-based default durations and active physician-choice prompts, to influence PPI prescribing workflows. Changes are embedded in routine practice so clinicians retain full authority to modify prescriptions. The study compares prescribing patterns across the different EHR configurations to see if defaults change behavior while monitoring for safety and workflow impact. Eligible participants are UCLA primary care physicians with at least 25% clinical full-time equivalency.

Why it matters

Potential benefit: If successful, this could reduce unnecessary long-term PPI use and lower patients' medication exposure and related risks.

How similar studies have gone: Previous EHR default and nudging interventions have reduced inappropriate prescribing in other settings, although effectiveness varies by context and design.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* UCLA Health primary care physicians who have a clinical full-time equivalency of at least 25%.

Exclusion Criteria:

* Physicians with a clinical full-time equivalency of less than 25%

Where it's running

  • UCLA Health System
    Los Angeles, California, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.