Optimizing oxygen flow rates during intubation in neonates and infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the optimal oxygen flow rate during tracheal intubation in neonates and infants using the C-MAC video laryngoscope. It compares low-flow and high-flow supplemental oxygen to determine if there is a significant difference in outcomes. Eligible participants will undergo pre-oxygenation and anesthesia induction before intubation, with careful monitoring of vital signs throughout the procedure. The study aims to enhance airway management practices in pediatric anesthesia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Pediatric patients requiring oral or nasal tracheal intubation for elective, semi-elective, or urgent surgical and non-surgical indications.
* Neonates and infants up to 52 weeks postconceptual age, with legal guardians providing written informed consent before the intervention

Exclusion Criteria:

* Prediction of difficult intubation upon physical examination or previous history of difficult intubation, mandating a technique different than direct laryngoscopy to secure the airway;
* Congenital heart disease demanding FiO2 \< 1.0
* Cardiopulmonary collapse requiring advanced life support
* Intubation for emergency surgical and non-surgical indications.

Where it's running

• Children's Hospital of Philadelphia
  Philadelphia, Pennsylvania, United States Recruiting
• Perth Children's Hospital
  Perth, Western Australia, Australia Recruiting
• Hospital Municipal Infantil Menino Jesus, Servicos Medicos de Anestesia
  São Paulo, São Paulo, Brazil Recruiting
• Dept. Anesthesia, The Hospital for Sick Children
  Toronto, Ontario, Canada Recruiting
• Dept. Anesthesia, Montreal Children's Hospital, McGill University Health Centre
  Montreal, Canada Recruiting
• Department of Cardiac Anesthesiology and Intensive Care Medicine, Charité Universitätsmedizin
  Berlin, Germany Recruiting

Study contacts

• Study coordinator: Alexander Fuchs, MD
• Email: alexander.fuchs@insel.ch
• Phone: +41 31 632 52 01

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ultrasound Measurements and Age-Related Anatomy to Guide LMA Placement

  This study tests whether ultrasound measurements of the upper airway and age-related anatomy affect how easily and accurately a laryngeal mask is placed in young adults and older adults.

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• AI-assisted ultrasound check for LMA placement in adults

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• I-scoop vs C-Mac D-Blade for airway management with spontaneous breathing

  This study tests whether the i-scoop videolaryngoscope makes airway management with the patient breathing on their own and light sedation easier and safer than the C-Mac D-Blade in adults having surgery under general anesthesia.

  Recruiting Hannover Medical School · Hanover, Lower Saxony · NCT07624162

• Comparing two videolaryngoscopes for placing breathing tubes in infants

  This trial will test whether the BESDATA BD-DF videolaryngoscope works as well as the McGRATH MAC for placing breathing tubes on the first try in infants aged 6 months to 3 years during elective surgery.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07351227

• Finding the ventilation pressure that prevents air from entering the esophagus during anesthesia induction

  This test tries to find the ventilation pressure during anesthesia induction that prevents air from entering the esophagus in adults having elective general surgery.

  Recruiting Affiliated Hospital of Jiaxing University · Jiaxing · NCT07340255

• SaCoVLM™ video laryngeal mask for airway management by military medics

  This project will test whether the SaCoVLM™ video laryngeal mask helps military medics with limited intubation experience manage airways safely during simulation and in sedated elective surgery patients.

  Recruiting Charles University, Czech Republic · Prague, Prague · NCT07249983

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.