Optimizing medication for frail older people using multidose drug systems
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug
This study is testing whether a special medication review can help frail older adults who take many pills feel better by reducing their medications in a safe way.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 380 (estimated) |
| Ages | 75 Years and up |
| Sex | All |
| Sponsor | SIR Institute for Pharmacy Practice and Policy Academic / other |
| Locations | 1 site (Leiden, Zuid Holland) |
| Trial ID | NCT05609981 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of a clinical medication review combined with a deprescribing toolbox on reducing the number of medications in frail older adults who use multidose drug dispensing systems. Conducted in 38 community pharmacies in the Netherlands, the trial will involve pharmacists trained to perform a structured 5-step review process with patients aged 75 and older who are on more than 10 medications. The intervention aims to enhance patient-centered care by incorporating patient preferences and follow-up evaluations to ensure effective deprescribing. The study will compare outcomes between patients receiving the intervention and those receiving usual care.
Who should consider this trial
Good fit: Ideal candidates are frail older adults aged 75 and older who are using a multidose drug dispensing system and are on 10 or more chronic medications.
Not a fit: Patients who have received a clinical medication review in the past 12 months or those living in nursing homes may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce unnecessary medications in frail older adults, improving their overall health and quality of life.
How similar studies have performed: Other studies have shown promising results with similar deprescribing approaches, indicating potential for success in this trial.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * using a multidose drug dispensing system * hyperpolypharmacy patient (using 10 drugs or more) * age: 75 years or older Exclusion Criteria: * received a CMR in the previous 12 months * incapacitated * patients for whom the general practitioner is not the primary practionar * expected lifespan of less than six motnhs * patients who live in a nursing home
Where this trial is running
Leiden, Zuid Holland
- SIR Institute for Pharmacy Practice and Policy — Leiden, Zuid Holland, Netherlands (Recruiting)
Study contacts
- Study coordinator: Gert Baas, MSc
- Email: g.w.baas@sirstevenshof.nl
- Phone: +31 71 5766157
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.