Optimizing lung pressure in children with respiratory distress using advanced imaging
Official title: Assessing Optimal Positive End-expiratory Pressure (PEEP) Using Electrical Impedance Tomography (EIT) During a PEEP Titration Protocol in Mechanically Ventilated Children with Pediatric Acute Respiratory Distress Syndrome (PARDS)
Run by Children's Hospital Los Angeles · NCT06684119 · Data updated 2026-11-12
This study is testing a new way to adjust breathing support in children with severe lung problems to see if it helps them breathe better than the usual methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 0 Years to 18 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Children's Hospital Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | December 10, 2024 |
| Main results expected | January 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | February 7, 2025 |
| Trial ID | NCT06684119 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children under 18 years old who are on invasive mechanical ventilation and meet the criteria for pediatric acute respiratory distress syndrome.
✕Probably not a fit
Patients who may not benefit from this study include those with contraindications to EIT, hemodynamic instability, or specific cardiac conditions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to optimize positive end-expiratory pressure (PEEP) in pediatric patients suffering from Acute Respiratory Distress Syndrome (PARDS) by utilizing Electrical Impedance Tomography (EIT). The study will compare the optimal PEEP identified through EIT metrics with the current guideline recommendations. Participants will undergo EIT monitoring while subjected to a PEEP titration protocol to assess differences in physiological metrics. The goal is to find a balance between lung overdistention and collapse for improved respiratory outcomes.
Why it matters
Potential benefit: If successful, this approach could lead to more effective ventilation strategies for children with respiratory distress, potentially improving their recovery outcomes.
How similar studies have gone: While the use of EIT in this context is relatively novel, similar studies have shown promise in optimizing ventilation strategies in adult populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any person who is less than 18 years of age * is on invasive mechanical ventilation * is not spontaneously breathing * meets PARDS criteria Exclusion Criteria: * Contraindication to the use of EIT * Hemodynamic instability * Contraindications to hypercapnia * patients with uncuffed endotracheal or tracheostomy tubes * diagnosis of pneumothorax or bronchopleural fistula * non-conventional ventilation * any patient on extra-corporeal membrane oxygenation (ECMO) support * less than 1 week post-operatively from cardiac surgery * the following cardiac diagnoses: Glenn or Fontan physiology, significant right to left shunt * Corrected Gestational Age \< 37 weeks * pregnancy
Where it's running
-
Children's Hospital Los Angeles
Los Angeles, California, United States Recruiting
Study contacts
- Study coordinator: Hayden Leeds, MD
- Email: hleeds@chla.usc.edu
- Phone: 3233617939
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.