Optimizing emergency tracheal intubation techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate a combined strategy to reduce complications associated with emergency tracheal intubation in adults experiencing vital distress. The approach includes the systematic use of rocuronium as a paralytic agent, bag face-mask ventilation prior to intubation, and the use of a Gum Elastic Bougie (GEB) during the first intubation attempt. Previous studies have indicated that these individual interventions can lower the incidence of peri-intubation complications, but their combined effect has not been assessed. The outcomes will be recorded immediately after the out-of-hospital period and further data will be collected from medical records 28 days post-inclusion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.
* Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.

Exclusion Criteria:

* Patient presenting of a contraindication to succinylcholine, and/or rocuronium, and/or sugammadex (rocunorium antagonist).
* Patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis).
* Patient that are not members of a medical aid scheme (beneficiary or main member).
* Patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship/curatorship.

Where it's running

• CHU d'Angers
  Angers, France Recruiting
• CH Carnelle Portes de l'Oise
  Beaumont-sur-Oise, France Recruiting
• AP-HP - Hôpital Avicenne
  Bobigny, France Recruiting
• CHU de Bordeaux - Hôpital Pellegrin
  Bordeaux, France Recruiting
• CH de Pontoise René Dubos
  Cergy-Pontoise, France Recruiting
• AP-HP - Hôpital Henri Mondor
  Créteil, France Recruiting

Study contacts

• Principal investigator: Xavier COMBES, Pr — Université Hospital, Bordeaux
• Study coordinator: Xavier COMBES, Pr
• Email: xavier.combes@chu-bordeaux.fr
• Phone: 05 56 79 49 47

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hyperangulated vs. Macintosh blades for obstetric intubation

  This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT07667010

• Help for uninsured kids: connect to NJ FamilyCare in the ED

  This ED-based program tries to see if uninsured children can enroll or re-enroll in NJ FamilyCare by giving families direct help and a quick survey about barriers.

  Recruiting Hackensack Meridian Health · Hackensack, New Jersey · NCT07594782

• Pain monitoring with ANI during rapid sequence induction

  This study tests whether the Analgesia Nociception Index (ANI) can measure pain during rapid sequence induction in adults undergoing tracheal intubation.

  Recruiting Centre Hospitalier Princesse Grace · Monaco · NCT07588165

• Video laryngoscopy versus direct laryngoscopy for initial tracheal intubation in children

  This trial tests whether using a video laryngoscope on the first try helps doctors successfully place a breathing tube in children undergoing surgery more often than a direct laryngoscope.

  Recruiting Hospital Clinico Universitario de Santiago · Santiago de Compostela, A CORUÑA · NCT07495436

• Tracheal Tube Cuff Pressure and Postoperative Hoarseness and Pain

  This observational study looks at whether cuff pressure and other factors during surgery are linked to throat pain, hoarseness, cough, or minor bleeding after elective surgeries in adults.

  Recruiting Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande Do Sul (RS) · NCT07264179

• SaCoVLM™ video laryngeal mask for airway management by military medics

  This project will test whether the SaCoVLM™ video laryngeal mask helps military medics with limited intubation experience manage airways safely during simulation and in sedated elective surgery patients.

  Recruiting Charles University, Czech Republic · Prague, Prague · NCT07249983

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.