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Optimizing care for Staphylococcus aureus bacteremia

Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB): A Stepped Wedge Clinical Trial Evaluating the Effectiveness of a Centralized S. Aureus Management Model

Not applicable Interventional University of Alberta · NCT06338176

This study is testing a new way to improve treatment for patients with Staphylococcus aureus bacteremia by using a standardized care plan and a dedicated team to ensure everyone gets the best care possible.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1800 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Alberta Academic / other
Locations101 sites (Athabasca, Alberta and 100 other locations)
Trial IDNCT06338176 on ClinicalTrials.gov

What this trial studies

This study aims to enhance the management of Staphylococcus aureus bacteremia (SAB) across Alberta by implementing a standardized clinical care pathway. It builds on previous pilot work that demonstrated improved adherence to evidence-based care indicators through timely infectious disease consultations. The study will utilize a stepped wedge design across various acute care sites, where a centralized SAB care team will receive automated notifications of positive blood cultures for S. aureus. This approach seeks to improve patient outcomes by ensuring that all patients receive optimal care based on established guidelines.

Who should consider this trial

Good fit: Ideal candidates for this study are adults over 18 years old who have confirmed S. aureus bacteremia and are admitted to designated acute care sites in Alberta.

Not a fit: Patients who are deemed to have imminent or inevitable death or those transferred from out-of-province centers with a pre-existing SAB diagnosis may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could significantly reduce morbidity and mortality associated with Staphylococcus aureus bacteremia.

How similar studies have performed: Previous studies have shown success in improving care for Staphylococcus aureus bacteremia through enhanced infectious disease consultations, indicating that this approach has potential.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Age greater than 18 years at the time of hospital admission
* Confirmed S. aureus bacteremia by blood culture performed at a laboratory in Alberta, Canada
* Admitted to a designated acute care site in Alberta, Canada

Exclusion Criteria:

* The treating team believes death is imminent or inevitable .
* GCD are C-level within 48 hours of admission.
* The patient is transferred in from an out-of-province acute care center with a pre-existing SAB diagnosis.

Where this trial is running

Athabasca, Alberta and 100 other locations

+51 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Staph Aureus Bacteremiacare pathwayinfectious disease consultation
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.