Optimizing brain stimulation for epilepsy surgery planning
Official title: A Study of the Effect of Intracerebral Electrical Stimulation on the Optimisation of Presurgical Planning in Drug-refractory Partial Epilepsy (StiMiC)
Run by University Hospital, Toulouse · NCT03738072 · Data updated 2026-11-12
This study is testing if using special brain stimulation techniques can help doctors better plan surgery for patients with epilepsy who don’t respond to medication.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 12 Years to 65 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Status | Recruiting |
| Started | November 14, 2018 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | May 7, 2026 |
| Trial ID | NCT03738072 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 12 to 65 years who are undergoing SEEG for drug-refractory epilepsy.
✕Probably not a fit
Patients outside the age range of 12 to 65 years or those who do not require SEEG may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of intracerebral electrical stimulation to improve presurgical planning for patients with drug-refractory epilepsy. Patients undergoing stereo-electro-encephalography (SEEG) will receive standard stimulation frequencies alongside new frequencies based on their seizure characteristics and brain physiology. The goal is to determine if these additional frequencies enhance the identification of the seizure onset zone, which is crucial for effective surgical intervention. The study will compare the effectiveness of standard and research stimulation conditions in mapping seizure activity.
Why it matters
Potential benefit: If successful, this approach could lead to more precise surgical planning and better outcomes for patients with drug-refractory epilepsy.
How similar studies have gone: While the use of electrical stimulation in epilepsy management is established, the exploration of a broader range of stimulation frequencies is a novel approach that has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients undergoing a stereo-electro-encephalography (SEEG), age 12 to 65 years old. Exclusion Criteria: * usual excluding criteria for a SEEG.
Where it's running
-
CHU de Toulouse
Toulouse, France Recruiting
Study contacts
- Principal investigator: Jonathan Curot, MD — CHU of Toulouse
- Study coordinator: Jonathan Curot, MD
- Email: curot.j@chu-toulouse.fr
- Phone: 05 61 77 56 08
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.