Optimizing blood flow to protect the brain after cardiac arrest
NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study
This study is testing a personalized blood pressure management plan to see if it can help protect the brains of people who have had a cardiac arrest.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 49 (estimated) |
| Ages | 21 Years to 79 Years |
| Sex | All |
| Sponsor | National University Hospital, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT05679739 on ClinicalTrials.gov |
What this trial studies
This proof of concept study evaluates an individualized blood pressure management strategy aimed at enhancing cerebral blood flow in patients who have experienced out-of-hospital cardiac arrest. The approach involves using advanced monitoring techniques, including transcranial Doppler ultrasound and near-infrared spectroscopy, to tailor blood pressure targets for each patient. The effectiveness of this strategy will be assessed by measuring levels of neuron-specific enolase, a biomarker for brain injury, at baseline and 72 hours post-intervention. The study aims to recruit 49 patients to determine if this personalized approach can reduce brain injury compared to standard care.
Who should consider this trial
Good fit: Ideal candidates are adults aged 21 to 79 who are comatose following a return of spontaneous circulation after cardiac arrest.
Not a fit: Patients aged 80 and older, pregnant individuals, or those with limitations on care may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved brain recovery and outcomes for patients who suffer cardiac arrest.
How similar studies have performed: While this approach is innovative, similar studies targeting cerebral perfusion have shown promise, but this specific strategy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. At least 21 years of age 2. Comatose defined as not being able to obey verbal commands and no verbal response to pain after sustained ROSC. Exclusion Criteria: 1. ≥ 80 years old at time of enrolment 2. Pregnant patients 3. Limitations of care or life support therapy withdrawn within 24 hours of admission
Where this trial is running
Singapore
- National University Heart Centre, Singapore — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Shir Lynn Lim — National University Hospital, Singapore
- Study coordinator: Shir Lynn Lim
- Email: shir_lynn_lim@nuhs.edu.sg
- Phone: 69082222
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.