Optimizing blood flow to protect the brain after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This proof of concept study evaluates an individualized blood pressure management strategy aimed at enhancing cerebral blood flow in patients who have experienced out-of-hospital cardiac arrest. The approach involves using advanced monitoring techniques, including transcranial Doppler ultrasound and near-infrared spectroscopy, to tailor blood pressure targets for each patient. The effectiveness of this strategy will be assessed by measuring levels of neuron-specific enolase, a biomarker for brain injury, at baseline and 72 hours post-intervention. The study aims to recruit 49 patients to determine if this personalized approach can reduce brain injury compared to standard care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. At least 21 years of age
2. Comatose defined as not being able to obey verbal commands and no verbal response to pain after sustained ROSC.

Exclusion Criteria:

1. ≥ 80 years old at time of enrolment
2. Pregnant patients
3. Limitations of care or life support therapy withdrawn within 24 hours of admission

Where it's running

• National University Heart Centre, Singapore
  Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Shir Lynn Lim — National University Hospital, Singapore
• Study coordinator: Shir Lynn Lim
• Email: shir_lynn_lim@nuhs.edu.sg
• Phone: 69082222

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Pain after out-of-hospital cardiac arrest and resuscitation

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• Measuring airway opening during out-of-hospital cardiac arrest

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• AI-guided chest compressions for personalized CPR

  This project will test an AI app that analyzes arterial pressure waveforms to guide where rescuers compress the chest for adults with out-of-hospital cardiac arrest.

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• Ventilation Feedback in EMS Resuscitation (ventilation during CPR)

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• Preventing rearrest after out-of-hospital cardiac arrest with a paramedic post-ROSC care protocol

  This project will test whether a structured prehospital post-resuscitation protocol delivered by paramedics can lower the chance of rearrest in adults who regain a pulse after out-of-hospital cardiac arrest.

  Recruiting Phase 2/3 Siriraj Hospital · Bangkok Noi, Bangkok · NCT07239908

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.