Optimizing assessment strategies for carotid artery stenosis
Official title: Cohort of Optimized Assessment Strategy of Carotid Artery Stenosis
Run by Peking Union Medical College Hospital · NCT05629000 · Data updated 2026-11-12
This study is testing different imaging methods to see which ones work best for checking carotid artery blockages and their effects on the brain in people undergoing surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | January 1, 2015 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | November 29, 2022 |
| Trial ID | NCT05629000 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with severe carotid artery stenosis (≥50%) or near-occlusion who are scheduled for carotid endarterectomy.
✕Probably not a fit
Patients with contraindications to imaging examinations or those who refuse to sign informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to enhance the evaluation of carotid artery stenosis by utilizing multiple imaging techniques, including MRI, CT, and ultrasound. It focuses on identifying the best strategies for assessing cerebral lesions and perfusion, as well as the characteristics of carotid plaques. Participants will undergo imaging examinations before and after carotid revascularization surgery, with data on their basic characteristics, imaging results, and biological samples collected for analysis.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and treatment strategies for patients with carotid artery stenosis.
How similar studies have gone: While similar approaches using multi-modal imaging have been explored, this specific optimization strategy is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram; 2. patients received carotid endarterectomy at Peking Union Medical College Hospital Exclusion Criteria: (1) Any contraindication to image examination; (3) refuse to sign the Informed consent.
Where it's running
-
vascular surgery department of PUMCH
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: Zhichao Lai, MD
- Email: zhichao_lai@126.com
- Phone: 01069152500
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Photon-counting CT vs conventional CT for carotid plaque in people with carotid artery stenosis
This study tests whether photon-counting CT gives clearer, more detailed pictures of carotid plaques compared with standard CT in patients with carotid artery stenosis to help characterize plaque features.
-
Carotid artery stent for people with carotid narrowing who are high risk for surgery
This study will try a carotid artery stent system in adults with carotid artery narrowing who are considered high risk for carotid endarterectomy.
-
Balloon guide catheter plus filter protection during carotid artery stenting
This trial tests whether adding a balloon guide catheter to the usual distal filter during carotid artery stenting reduces debris-related brain injury in adults with symptomatic (≥50%) or asymptomatic (≥70%) carotid stenosis scheduled for stenting.
-
Ultra-Intensive Lipid-Lowering Therapy in Carotid Artery Stenosis: PCSK9 Inhibitor Plus Statin vs Statin Alone
This study tests whether adding a PCSK9 inhibitor to statin therapy improves the amount of atherosclerosis in people with carotid artery stenosis compared to statin therapy alone.
-
Ultrasound screening and combined treatment strategies for people with coronary and neck artery narrowing.
This project uses Doppler ultrasound to screen people with coronary artery disease scheduled for elective PCI to see if finding and managing neck artery narrowings together with heart procedures leads to better outcomes.
-
Evaluating a new system for protecting the brain during carotid artery procedures
This study is testing a new device to see if it can help protect the brain during carotid artery procedures for people with narrowed arteries.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.