Optimizing antibiotic choices for newborns with suspected early-onset sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter, non-randomized pre–post implementation study in Dutch hospitals. A bundled antibiotic stewardship program combining the EOS calculator, PCT-guided therapy, and IV-to-oral switch protocols will be actively implemented using a multicomponent strategy. Clinical and implementation outcomes will be compared before and after rollout, with attention to antibiotic use, duration of therapy, safety outcomes, and adherence to the interventions. The aim is to reduce variation in care and safely decrease unnecessary antibiotic exposure in newborns.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Neonates born at 34 weeks of gestation or later
* 0-3 days old

Exclusion Criteria:

* stillborn neonates

Where it's running

• Noordwest Ziekenhuisgroep
  Alkmaar, Netherlands Recruiting
• Gelre Ziekenhuis
  Apeldoorn, Netherlands Recruiting
• Albert Schweitzer Ziekenhuis
  Dordrecht, Netherlands Recruiting
• Catharina Ziekenhuis
  Eindhoven, Netherlands Recruiting
• Treant Ziekenhuis
  Emmen, Netherlands Recruiting
• Admiraal de Ruyter Ziekenhuis
  Goes, Netherlands Recruiting

Study contacts

• Study coordinator: Liesanne E. J. Van Veen, MD
• Phone: +31628138839

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.