Optimizing and reinforcing walking skills in people with severe multiple sclerosis using high-intensity circuit training and telerehabilitation.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with primary or secondary progressive MS, preserved cognition (MMSE >24), and marked gait impairment (EDSS ≥6.5) will complete a supervised high-intensity, task-oriented circuit training program (about 12 sessions) to practice and consolidate motor skills. After the supervised phase, participants will be offered a telerehabilitation program intended to maintain gains over a six-month follow-up. The study will monitor feasibility, safety, and changes in gait and balance using standardized outcome measures at baseline, post-intervention, and during follow-up. The intervention is delivered at Ferrara University Hospital with remote components for the maintenance phase.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of primary or secondary progressive multiple sclerosis according to the McDonald criteria.
* Mini-Mental State Examination (MMSE) score \> 24.
* Expanded Disability Status Scale (EDSS) score ≥ 6.5.

Exclusion Criteria:

* Presence of other psychiatric or neurological disorders.
* Cardiopulmonary, renal, or liver diseases.
* Pregnancy.
* Modifications in drug treatment within the last 3 months.

Where it's running

• Ferrara University Hospital
  Ferrara, Fe, Italy Recruiting

Study contacts

• Study coordinator: Sofia Straudi, MD, PhD
• Email: sofia.straudi@unife.it
• Phone: +390532238720

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Treadmill-based virtual reality walking training for MS patients

  This study tests whether a treadmill with virtual reality and smart socks can help people with multiple sclerosis walk better and feel safer in daily life.

  Recruiting Shepherd Center, Atlanta GA · Atlanta, Georgia · NCT07927439

• Virtual Reality and Mental Practice to Improve Balance and Walking in Relapsing MS

  This study tests whether virtual reality training or mental practice can improve balance and walking in people with relapsing–remitting multiple sclerosis.

  Recruiting Cairo University · Giza, Giza Governorate · NCT07918339

• REAL-MS: A Look at Autologous Stem Cell Transplant vs High-Efficacy MS Therapies in Real-World Care

  This study tests how AHSCT compares to high-efficacy MS medicines in adults treated in routine clinical care.

  Recruiting Imperial College London · London and 2 other locations · NCT07899502

• Tolebrutinib in real-world MS care for patients treated by clinicians

  This real-world study sees how tolebrutinib is used for multiple sclerosis patients and what outcomes look like in everyday practice.

  Recruiting Sanofi · Marina, Abu Dhabi Emirate · NCT07898371

• Pilates via live video vs. prerecorded videos for people with multiple sclerosis

  This study tests whether live, coach-led Pilates sessions through video calls are more beneficial than prerecorded Pilates videos for adults with MS.

  Recruiting Yuzuncu Yil University · Van · NCT07893925

• Cooling During Inpatient Rehab for People with MS

  This trial tests whether wearing a cooling vest during intensive training can reduce fatigue and improve walking, strength, balance, and cognition in people with multiple sclerosis during a 3-week inpatient rehab stay.

  Recruiting Klinik Valens · Valens, Canton of St. Gallen · NCT07852156

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.