Opioid-free anesthesia for lung surgery
Official title: Opioid-Free Combined Anesthesia Under Spontaneous Breathing for Video-Assisted Thoracoscopic Surgery of Pulmonary Nodules: A Multicenter, Open-Label, Randomized Controlled, 2x2 Factorial Design Clinical Study
Run by Tongji Hospital · NCT06367218 · Data updated 2026-11-12
This study is testing if using an opioid-free anesthesia approach during lung surgery helps patients recover better and have fewer complications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 480 (estimated) |
| Sponsor | Tongji Hospital Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | July 1, 2026 |
| Study ends | August 1, 2026 |
| Registry record updated | January 3, 2025 |
| Trial ID | NCT06367218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 70 with ASA grades 1-2 scheduled for VATS pulmonary nodule surgery.
✕Probably not a fit
Patients requiring complex surgical procedures or those with serious adverse events during the perioperative period may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of opioid-free combined anesthesia with preserved spontaneous breathing during video-assisted thoracoscopic surgery (VATS) for lung nodules. It employs a multicenter, randomized controlled design with four patient groups receiving different anesthesia strategies. The aim is to assess postoperative recovery, lung function, and complications across various phases of care. The study is conducted by experienced anesthetists and thoracic surgeons in six hospitals in China.
Why it matters
Potential benefit: If successful, this approach could lead to faster recovery and fewer complications for patients undergoing lung surgery.
How similar studies have gone: While the opioid-sparing strategy is gaining attention, high-level clinical evidence supporting its benefits in this specific context is still lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ASA grades 1-2 2. Age \> 18 years and \< 70 years 3. Male or female patients 4. VATS pulmonary nodule operation is planned under general anesthesia 5. Voluntarily participate in the study and sign the informed consent Exclusion Criteria: 1. Subject's operation is aborted 2. Serious adverse events, complications or special physiological changes during the perioperative period should not be continued 3. Expansion of surgical scope: resection of complex lung segment or complex lung lobectomy, thoracoscopic assisted small-incision surgery with enlarged incision, requiring pulmonary blood Tracheoplasty or bronchoplasty, partial pericardiectomy or conversion to thoracotomy 4. Those who need a second operation within a month 5. The patient or his/her guardian requests to withdraw on his/her own 6. Reasons why other researchers think the study needs to be discontinued
Where it's running
-
Tongji Hospital
Wuhan, Hubei, China Recruiting
Study contacts
- Study coordinator: Hui Xu, Professor
- Email: huixu@tjh.tjmu.edu.cn
- Phone: (86)-13971001596
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.