Clinical trial Recruiting at 1 site Interventional Ages 18 to 70 Women only

Online weight loss program for sexual minority women

Official title: Optimizing an Online Behavioral Weight Loss Intervention and Novel Culturally Tailored Components for Sexual Minority Women: MOST Optimization Phase

Run by The Miriam Hospital · NCT05775497 · Data updated 2026-11-12

This study tests an online weight loss program designed specifically for sexual minority women to see if it can help them overcome unique challenges and lose weight effectively.

Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexWomen only
Enrollment88 (estimated)
SponsorThe Miriam Hospital
Academic / other
Locations1 site (Providence, Rhode Island)
StatusRecruiting
StartedMay 1, 2024
Main results expectedSeptember 1, 2025
Study endsDecember 29, 2025
Registry record updatedDecember 27, 2024
Trial IDNCT05775497 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include sexual minority women aged 18-70 with a BMI between 25-50 who are interested in losing weight.

Probably not a fit

Patients with serious mental or physical health conditions that could increase treatment risks may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention focuses on addressing obesity among sexual minority women through an online behavioral weight loss program. The program incorporates culturally tailored components that target specific barriers faced by this group, such as minority stress, low social support, and negative body image. The approach is designed to be effective, low-cost, and scalable, making it accessible to a wider audience. The study includes qualitative feedback from participants to enhance the program's relevance and usability.

Why it matters

Potential benefit: If successful, this program could significantly improve weight loss outcomes and overall health for sexual minority women.

How similar studies have gone: Other studies have shown success with culturally tailored interventions for specific populations, suggesting potential for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
* Assigned female at birth and currently identify as female
* Self-identify a minority sexual orientation (e.g.,lesbian, bisexual)
* BMI=25-50kg/m2
* 18-70 years old
* Interested in losing weight
* Regular internet and e-mail access
* No significant weight loss within past 6 months (\>5%)
* Fluent in English
* Able to participate in moderate physical activity
* Not currently enrolled in a weight loss program
* Not currently taking weight-loss medication
* Not currently pregnant or trying to get pregnant
* Participated in a previous Phase of this study
* Reports a serious mental/physical health condition that would increase potential risks of treatment to the participant (e.g., active symptoms of psychosis, suicidality, mania, alcohol/substance use, or a medical condition that is serious, active, unstable, and degenerative (e.g., CHF)).

Where it's running

  • Weight Control and Diabetes Research Center
    Providence, Rhode Island, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.