One-year web-based prevention program with nurse support after hospitalization for decompensated heart failure
Intensive Prevention Program After Decompensated Heart Failure
NA · Herzzentrum Bremen · NCT07472660
This will test whether a one-year web-based education and support program led by heart-failure nurses can lower rehospitalizations and improve quality of life for adults hospitalized with decompensated heart failure.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Herzzentrum Bremen (other) |
| Locations | 1 site (Bremen) |
| Trial ID | NCT07472660 on ClinicalTrials.gov |
What this trial studies
Adults hospitalized for decompensated heart failure with reduced ejection fraction will be prospectively enrolled. Participants will be assigned to a 12-month heart-failure nurse-guided web-based self-learning and support program and compared with standard post-discharge care. The intervention uses a patient portal, e-learning modules, mobile access, and regular contact with specialized heart-failure nurses to reinforce guideline-based therapy and self-management. Key outcomes include rates of rehospitalization and changes in quality of life over one year.
Who should consider this trial
Good fit: Ideal candidates are adults 18–80 years hospitalized for symptomatic decompensated heart failure with reduced ejection fraction (≤40%), elevated NT‑proBNP, life expectancy >2 years, and access to the internet who can participate in a nurse-guided web program.
Not a fit: Patients with ejection fraction >40%, persistent NYHA IV at discharge, reversible causes of heart failure, major non-cardiac conditions limiting survival or exercise, inability to consent, or no internet access are unlikely to benefit.
Why it matters
Potential benefit: If successful, the program could reduce rehospitalizations and improve patients' quality of life by strengthening education and nurse-led support after discharge.
How similar studies have performed: Previous trials of nurse-led and telehealth interventions for heart failure have shown mixed results, with some reductions in readmissions and improved self-management but inconsistent effects across studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hospitalization due to symptomatic HF NYHA II-IV, defined according to valid international guidelines, including signs of congestion, ejection fraction ≤40%, elevated NTproBNP * Age 18 - 80 years * Life expectancy \> 2 years * Access to internet, physical and mental ability and consent to participate in a HFN-guided web-based prevention program Exclusion Criteria: * Persistent NYHA IV at discharge * Reversible cause of heart failure (such as tachycardiomyopathy, acute myocarditis, pacemaker-induced HF, etc.) * Ejection fraction \>40% (HFmrEF, HFpEF) * Patient refusal or inability to give informed consent * Participation in another trial * Exercise limitations due to clinical conditions not related to HF, e.g. disabling orthopedic, rheumatological, hematooncological or neurological diseases (such as disabling stroke), severe lung diseases (such as COLD GOLD IV) * Any major non-cardiac condition that would adversely affect survival during the duration of the study, e.g. malignant comorbidities with prognosis \< 2 years or other severe comorbidities (such as end-stage liver cirrhosis) with prognosis \< 2 years * Inability to cooperate with the protocol, e.g. chronic active drug and/or alcohol abuse, severe mental disorders (such as dementia), deafness or severe language barrier (with no sufficient options for translation), inability to come to the study visits for endpoint assessment
Where this trial is running
Bremen
- Bremen Institute for Heart- and Circulation Research — Bremen, Germany (RECRUITING)
Study contacts
- Study coordinator: Stephan Ruehle
- Email: stephan.ruehle@gesundheitnord.de
- Phone: +494218794684
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Heart Failure, Heat Failure Intervention, Heart Failure Nurse, Web-based Prevention Program