One-time low-dose CT scan for lung cancer screening
Official title: Non-risk Based Lung Cancer Screening With One-time Low-dose Computed Tomography: a Prospective Cohort Study
Run by The First Affiliated Hospital of Guangzhou Medical University · NCT04938804 · Data updated 2026-11-12
This study is testing if a one-time low-dose CT scan can help find lung cancer early in people aged 40-74 living in Guangzhou, regardless of their risk factors.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 74 Years |
| Sex | All |
| Enrollment | 11000 (estimated) |
| Sponsor | The First Affiliated Hospital of Guangzhou Medical University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | December 12, 2015 |
| Main results expected | December 1, 2025 |
| Study ends | December 1, 2026 |
| Registry record updated | January 9, 2024 |
| Trial ID | NCT04938804 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are residents aged 40-74 years living in Guangzhou without a recent history of lung cancer or significant cancer-related symptoms.
✕Probably not a fit
Patients who have been diagnosed or treated for lung cancer in the past five years or have significant cancer-related symptoms may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Guangzhou Lung-Care Project is a single-arm, prospective cohort initiative aimed at early lung cancer detection using a one-time low-dose computed tomography (LDCT) scan. It recruits residents aged 40-74 from four communities in Guangzhou, focusing on the lung cancer detection rate among participants without high-risk factor restrictions. The study also examines the proportion of stage I lung cancer cases and investigates various factors associated with lung cancer development. Follow-up for post-screening management and survival outcomes is recorded to assess the effectiveness of the screening approach.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of lung cancer, potentially improving survival rates for patients.
How similar studies have gone: Other studies have shown success with similar low-dose CT screening approaches for lung cancer detection, indicating potential effectiveness.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Minimum age of 40 years among the residents in Guangzhou Exclusion Criteria: * Persons who had a diagnosis or treatment related to LC within the past 5 years, had undergone chest CT within the past year, or had significant cancer-related symptoms (e.g., hemoptysis, dyspnea, inability to climb two flights of stairs).
Where it's running
-
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Wenhua Liang, MD — The First Affiliated Hospital of Guangzhou Medical University
- Study coordinator: Wenhua Liang, MD
- Email: liangwh1987@163.com
- Phone: +86-02-83062808
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
ePRO in advanced lung cancer: emotional distress, brain metastasis, and symptom burden
This study tests how patients with advanced lung cancer—some with brain metastases—report emotional distress and symptoms over time using electronic questionnaires.
-
Urine VOC Test to Detect Lung Cancer in Never Smokers
A urine test that looks for volatile compounds is tested to see if it can help detect lung cancer in adults who have never smoked.
-
SI-B036 safety test in advanced and metastatic solid tumors
This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.
-
Guaraná Supplement for Cancer-Related Fatigue in People Undergoing Treatment
This study tests whether taking guaraná capsules helps reduce cancer-related fatigue and improve quality of life in adults with breast, lung, colorectal, or gastric cancer who are actively receiving treatment.
-
ENPP1/cGAS and FAP in Solid Tumors in Vietnamese Patients
This Vietnam-based study will test ENPP1, cGAS, and FAP expression in archived tumor samples from Vietnamese adults with solid cancers using immunohistochemistry.
-
Olive oil before lung cancer surgery to see if it lowers chylothorax
This study tests whether drinking 40 mL of extra-virgin olive oil a few hours before lung cancer surgery can reduce chylothorax after tumor removal.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.