Ondansetron and lidocaine instillation to ease postoperative pain after lower abdominal cancer surgery
Official title: Impact of Intraperitoneal Irrigation of Ondansteron in Combination With Lidocaine in Acute Postoperative Pain in Lower Abdominal Cancer Surgery: a Randomized Clinical Trial
Run by Assiut University · NCT07706348 · Data updated 2026-11-12
This study tests whether putting ondansetron together with lidocaine directly into the abdomen can reduce pain after lower abdominal cancer surgery.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 70 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Assiut University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | June 1, 2026 |
| Main results expected | July 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | July 15, 2026 |
| Trial ID | NCT07706348 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with ASA I–II status undergoing major lower abdominal cancer surgery, without contraindications to study drugs or significant comorbidities.
✕Probably not a fit
Patients with severe organ disease, obesity (BMI ≥30), chronic benzodiazepine use, or prior opioid dependence may not benefit and could be excluded or experience limited effect.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study investigates intraperitoneal administration of ondansetron in combination with lidocaine for managing acute postoperative pain in adults undergoing major lower abdominal cancer surgery. The trial spans Phases 1 and 2 and focuses on safety and preliminary efficacy in reducing pain while potentially limiting opioid-related side effects. Participants are adults with ASA I–II status and without major organ disease or other exclusions. The intervention aims to provide local analgesia at the surgical site through intraperitoneal instillation, leveraging potential anti-inflammatory and analgesic properties of ondansetron in addition to lidocaine. Outcomes will inform whether this combination merits further evaluation in larger trials.
Why it matters
Potential benefit: If successful, patients may experience better postoperative pain control and fewer opioid-related side effects.
How similar studies have gone: Previous work suggests intraperitoneal anesthetic techniques and 5-HT3 antagonists may reduce pain, but this exact combination is novel and exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II patients * scheduled for major lower abdominal cancer surgeries. Exclusion Criteria: * patients with known allergy to the study drugs, * significant cardiac, respiratory, renal or hepatic disease, * body mass index (BMI) ≥30 kg/m2; * allergy to study drugs * history of opioid use for pain management the time of enrolment or drug addiction, * who had used benzodiazepine chronically, * stroke or psychiatric disease that could affect the perception of pain.
Where it's running
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Assiut University - South Egypt Cancer Instiute
Asyut, Egypt Recruiting
Study contacts
- Study coordinator: shereen mamdouh kamal, professor
- Email: drshereenmamdouh@gmail.com
- Phone: +201006279209
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.