Omega-3 supplements for kids with migraines

Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids in Pediatric Migraine Patients

NA · University of North Carolina, Chapel Hill · NCT06899074

This study is testing if omega-3 supplements can help kids and teens aged 10-17 with migraines feel better and have fewer headaches.

Quick facts

PhaseNA
Study typeInterventional
Enrollment80 (estimated)
Ages10 Years to 17 Years
SexAll
SponsorUniversity of North Carolina, Chapel Hill (other)
Locations1 site (Chapel Hill, North Carolina)
Trial IDNCT06899074 on ClinicalTrials.gov

What this trial studies

This study evaluates the effects of omega-3 polyunsaturated fatty acid (PUFA) supplementation on children and adolescents aged 10-17 who suffer from migraines. Over a 12-week period, participants will be randomly assigned to receive either an omega-3 supplement or a placebo, with assessments conducted at the beginning and end of the study. The goal is to determine if omega-3 supplementation can reduce migraine frequency, severity, and associated psychological distress, thereby improving overall quality of life.

Who should consider this trial

Good fit: Ideal candidates are children and adolescents aged 10-17 with a diagnosis of migraine.

Not a fit: Patients with known allergies to fish or seafood, or those with significant neurological or psychiatric disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a new dietary intervention for managing pediatric migraines.

How similar studies have performed: While omega-3 supplementation has shown promise in adults with migraines, this approach in pediatric populations is novel and has not been rigorously tested before.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Males and females between the ages of 10 and 17 years
* Parent consent and subject assent
* Diagnosis of migraine based on the third edition of the International Classification of Headache Disorders (ICHD-3) criteria

Exclusion Criteria:

* Known allergy to fish or seafood
* Current use of an omega-3 dietary supplement
* Significant neurological or psychiatric disorders or developmental delays
* Non-English speaking
* Allergy to coconut
* Pregnancy

Where this trial is running

Chapel Hill, North Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Migraine

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.