Ofloxacin blood levels and side effects in older adults with bone and joint infections.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Older patients hospitalized for uncomplicated bone or joint infections who switch to oral ofloxacin will have residual serum ofloxacin measured on day 3 and complete a questionnaire about possible side effects. The team will link individual day-3 concentrations with the occurrence of at least one adverse effect judged attributable to ofloxacin. If an association is found, the analysis will estimate a threshold concentration associated with increased toxicity. The single-center design uses routine clinical monitoring and targeted sampling to inform therapeutic drug monitoring decisions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged over 65 years hospitalized at the University Hospital of Amiens for an uncomplicated bone and joint infections
* Indication for oral switch to ofloxacin

Exclusion Criteria:

* Patient refusing to participate in the study
* Patient under guardianship or curators or deprived of public rights
* Any liver or biliary injury
* Any contraindications to ofloxacin

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Principal investigator: Youssef BENNIS, MD — CHU Amiens
• Study coordinator: Youssef BENNIS, MD
• Email: bennis.youssef@chu-amiens.fr
• Phone: (33)32208700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.