Observing twin pregnancies and their offspring
Cohort of Twin Pregnancy and the Offspring
Fudan University · NCT05727085
This study looks at twin pregnancies and their babies to see how these pregnancies affect both the mothers and their children’s health and development over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Fudan University (other) |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT05727085 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a prospective cohort of twin pregnancies and their offspring to better understand the complications associated with twin pregnancies, such as gestational hypertension and twin-to-twin transfusion syndrome. Data will be collected from mothers regarding their pregnancy experiences and from offspring concerning their mental, physical, and sociodemographic development up to three years of age. Biological samples, including maternal blood and placental tissues, will also be collected at specific times throughout the study, which will last a total of six years, with the first 2.5 years dedicated to participant recruitment.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women over 18 years old who are expecting twins.
Not a fit: Patients with fetal chromosomal or congenital abnormalities or those who experience stillbirth may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of complications in twin pregnancies, benefiting both mothers and their children.
How similar studies have performed: While twin pregnancies have been studied, this specific approach focusing on molecular mechanisms and epigenetic differences in a cohort setting is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Maternal age \>18 years old. 2. Twin pregnancy. Exclusion Criteria: 1. Fetal chromosomal or congenital abnormalities. 2. Stillbirth.
Where this trial is running
Shanghai, Shanghai Municipality
- Obstetrics and Gynecology Hospital of Fudan University — Shanghai, Shanghai Municipality, China (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Twin Pregnancy