Clinical trial Recruiting at 1 site Observational Ages 18 and up Women only

Observing twin pregnancies and their offspring

Official title: Cohort of Twin Pregnancy and the Offspring

Run by Fudan University · NCT05727085 · Data updated 2026-11-12

This study looks at twin pregnancies and their babies to see how these pregnancies affect both the mothers and their children’s health and development over time.

Quick facts

Study typeObservational
Ages18 Years and up
SexWomen only
Enrollment1000 (estimated)
SponsorFudan University
Academic / other
Locations1 site (Shanghai, Shanghai Municipality)
StatusRecruiting
StartedOctober 15, 2023
Main results expectedJune 15, 2026
Study endsJune 15, 2029
Registry record updatedMarch 14, 2025
Trial IDNCT05727085 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are pregnant women over 18 years old who are expecting twins.

Probably not a fit

Patients with fetal chromosomal or congenital abnormalities or those who experience stillbirth may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to create a prospective cohort of twin pregnancies and their offspring to better understand the complications associated with twin pregnancies, such as gestational hypertension and twin-to-twin transfusion syndrome. Data will be collected from mothers regarding their pregnancy experiences and from offspring concerning their mental, physical, and sociodemographic development up to three years of age. Biological samples, including maternal blood and placental tissues, will also be collected at specific times throughout the study, which will last a total of six years, with the first 2.5 years dedicated to participant recruitment.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of complications in twin pregnancies, benefiting both mothers and their children.

How similar studies have gone: While twin pregnancies have been studied, this specific approach focusing on molecular mechanisms and epigenetic differences in a cohort setting is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Maternal age \>18 years old.
2. Twin pregnancy.

Exclusion Criteria:

1. Fetal chromosomal or congenital abnormalities.
2. Stillbirth.

Where it's running

  • Obstetrics and Gynecology Hospital of Fudan University
    Shanghai, Shanghai Municipality, China
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.