Observing the treatment of Graves' disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on patients diagnosed with Graves' disease hyperthyroidism, aiming to establish standard diagnosis and treatment procedures. Conducted at Ruijin Hospital, it involves a follow-up of patients to gather data that will support future research protocols. The study will assess the clinical manifestations and immune factors involved in the disease, particularly the role of CD4+ T cells. By documenting patient experiences and outcomes, the study seeks to enhance understanding and management of Graves' disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients aged 18-70 years old with normal BMI (18-25), who are diagnosed with Graves' disease hyperthyroidism in accordance with the 2016 American Thyroid Association's guidance at the first diagnosis, or patients who relapse after more than one year of medication withdrawal.

1. High metabolic symptoms such as fear of heat, sweating, and palpitations;
2. Diffuse enlargement of thyroid gland, B-ultrasound of thyroid gland indicates diffuse thyroid disease and increased blood flow of thyroid;
3. Serological detection of TSH levels decreased and FT3 and/or FT4 increased; meanwhile, TRAb was positive (TRAb\>1.75 IU/L);
4. Accompanied by thyroid infiltrating ocular signs or pretibial mucous edema.

Exclusion Criteria:

1. Patients with Graves' disease who have previously undergone radioactive iodine 131 or surgery;
2. Blood routine WBC\<3×109/L, neutrophils\<1.5×109/L, or accompanied by other malignant blood diseases;
3. Patients with other serious heart, liver, lung, kidney disease or malignant tumors;
4. In the past six months, there is a history of using immunosuppressants or other autoimmune diseases such as systemic lupus erythematosus, Sjogren's syndrome, etc.;
5. Pregnant and lactating women; Allergies to the drugs used in the treatment plan; and any situation (medical, psychological, social, or geographical factors) that may endanger the safety of the patient or prevent the patient from successfully participating in the study.

Where it's running

• Ruijin hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, Shanghai, China Recruiting

Study contacts

• Principal investigator: Weiqing Wang, MD,PhD — Shanghai Jiao Tong University School of Medicine
• Study coordinator: Yulin Zhou, MD,PhD
• Email: yulinzhou6@163.com
• Phone: 8621-64370045

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.