Observing the natural progression of spinocerebellar ataxia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The EUROSCA Natural History Study aims to determine and compare the rate of disease progression in various types of spinocerebellar ataxia (SCA1, SCA2, SCA3, and SCA6). It utilizes a validated ataxia scale to assess symptoms and quality of life, while also identifying predictors of disease progression and survival. The study includes substudies that focus on brain atrophy through MRI and the progression of peripheral neuropathy. This observational approach will provide valuable insights into the natural history of these conditions.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Progressive, otherwise unexplained ataxia
* Positive genetic testing for SCA1, SCA2, SCA3, and SCA6
* Written informed consent by the patient or his legal agent

Exclusion criteria:

None.

Where it's running

• Department of Neurology, University of Bonn
  Bonn, Germany Recruiting
• Department of Neurology, Medical University, Innsbruck
  Innsbruck, Austria Active not recruiting
• Université Libre de Bruxelles (ULB), Neurology Service - ULB Hôpital Erasme, ULB Laboratory of Experimental Neurology
  Brussels, Belgium Active not recruiting
• Hôpital de la Pitié-Salpêtrière, Département de Génétique
  Paris, France Active not recruiting
• Department of Neurology, St. Josef Hospital, University Hospital of Bochum
  Bochum, Germany Active not recruiting
• Department of Neurology, University Clinic Essen, University of Duisburg-Essen
  Essen, Germany Active not recruiting

Study contacts

• Study coordinator: Thomas Klockgether, Prof. Dr.
• Email: thomas.klockgether@ukb.uni-bonn.de
• Phone: +4922828715736

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Eye problems in dominant spinocerebellar ataxias

  This project tests whether adults with SCA1, SCA2, SCA3, or SCA27B have retinal or optic nerve changes by doing neurological and eye exams.

  Recruiting University Hospital, Montpellier · Montpellier, Hérault · NCT07019558

• Effects of Antrodia Cinnamomea on Spinocerebellar Ataxia Symptoms

  This study is testing whether a product made from Antrodia cinnamomea can help improve symptoms in people with spinocerebellar ataxia.

  Recruiting ALPS Biotech CO. LTD · Taipei · NCT06633003

• Registry for Spinocerebellar Ataxias in Hong Kong

  This study is creating a registry for spinocerebellar ataxias in Hong Kong to help understand the condition better by collecting information from people diagnosed with it and their family members.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT03336008

• Interposed Nucleus aDBS for Ataxia in SCA6

  A small, single-center study will try a cerebellar adaptive deep brain stimulation approach to help adults with Spinocerebellar Ataxia type 6.

  Recruiting University of Florida · Gainesville, Florida · NCT07325487

• Adaptive deep brain stimulation in the cerebellum for spinocerebellar ataxia type 6

  This will see if an implanted adaptive deep brain stimulator placed in the cerebellum can reduce movement and balance problems in adults with SCA6 who still have symptoms.

  Recruiting University of California, San Francisco · San Francisco, California and 1 other locations · NCT07288437

• Registry for patients with rare diseases

  This study is creating a central registry for people with rare diseases to help connect them with researchers and improve treatments.

  Recruiting Sanford Health · Sioux Falls, South Dakota · NCT01793168

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.