Observing the natural history of coronary artery disease using FFR measurements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enroll approximately 20,000 patients with Fractional Flow Reserve (FFR) measurements to evaluate the natural history of coronary lesions over a two-year period. The study will be conducted at multiple centers across Korea, focusing on clinical and imaging follow-up of participants. By tracking these patients, researchers hope to gain insights into the progression of coronary artery disease and the implications of FFR-guided interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 35 years and older
* FFR measurement on one and more coronary artery stenosis
* Willing and able to provide informed, written consent

Exclusion Criteria:

* Stenosis with TIMI\<3 flow
* Graft vessel
* Ejection fraction \< 30%
* Angiographic evidence of extreme tortuosity or calcified coronary vessels
* Suspected coronary spasm even after sufficient nitrate injected
* Life expectancy \<2 year
* Planned cardiac surgery or planned major non cardiac surgery
* Woman who are breastfeeding, pregnant or planning to become pregnant during the course of the study

Imaging study specific exclusion criteria

* visually-estimated angiographic reference segment diameter of \<2.75mm or \>4.0mm
* Inappropriate for IVUS/VH/OCT procedures : inability for imaging wire or catheter to pass through the tight stenosis, severe calcification, angulation

Where it's running

• Hallym University Sacred Heart Hospital
  Anyang, South Korea Recruiting
• Soon Chun Hyang University Hospital Bucheon
  Bucheon-si, South Korea Recruiting
• Chungbuk National University Hospital
  Cheongju-si, South Korea Recruiting
• Gangwon National Univ. Hospital
  Chuncheon, South Korea Recruiting
• Daegu Catholic University Center
  Daegu, South Korea Recruiting
• Keimyung University Dongsan Medical Center
  Daegu, South Korea Recruiting

Study contacts

• Principal investigator: Seung-Jung Park, MD,PhD — Asan Medical Center
• Study coordinator: Seung-Jung Park, MD, PhD
• Email: sjpark@amc.seoul.kr

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.