Observing the effects of proton therapy in lymphoma patients
Official title: Multicenter Registry Study on Proton Radiotherapy for Mediastinal Lymphomas
Run by University Hospital Heidelberg · NCT04613388 · Data updated 2026-11-12
This study tests if proton therapy can effectively treat young patients with mediastinal lymphoma while causing fewer side effects compared to traditional radiation methods.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Hospital Heidelberg Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Heidelberg) |
| Status | Recruiting |
| Started | August 1, 2018 |
| Main results expected | August 1, 2030 |
| Study ends | August 1, 2031 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT04613388 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with histologically confirmed lymphoma requiring mediastinal radiotherapy.
✕Probably not a fit
Patients under 18 years old or those who do not consent to participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to document the effectiveness and side effects of proton radiotherapy in patients with mediastinal lymphoma. It focuses on reducing therapy-associated toxicity, particularly in young patients who are at risk for long-term complications from conventional radiation methods. By utilizing modern radiation techniques like proton therapy, the study seeks to minimize radiation exposure to critical organs such as the heart and lungs. Data collected will help inform future treatment planning and feasibility for this patient population.
Why it matters
Potential benefit: If successful, this study could lead to safer treatment options for lymphoma patients, reducing long-term side effects associated with radiation therapy.
How similar studies have gone: Other studies have shown promising results with proton therapy in reducing side effects, indicating a potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Histologically confirmed lymphoma according to WHO * Patient consent * Patient age ≥18 years. * Presence of the need for mediastinal radiotherapy and the presumed benefit of mediastinal radiotherapy using protons in comparison to photon radiation (e.g. improved heart, lungs, and breast protection compared to photon radiation). * Ability of the patient to give consent Exclusion Criteria: Age \<18 years * Non-consent of the patient to the disclosure of his data * Cancellation of the patient's participation in the study
Where it's running
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University Hospital Heidelberg
Heidelberg, Germany Recruiting
Study contacts
- Principal investigator: Laila König, MD — University Hospital Heidelberg
- Study coordinator: Laila König, MD
- Email: laila.könig@med.uni-heidelberg.de
- Phone: +49 6221
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.