Clinical trial Recruiting at 1 site Observational Ages 18 and up

Observing the effects of proton therapy in lymphoma patients

Official title: Multicenter Registry Study on Proton Radiotherapy for Mediastinal Lymphomas

Run by University Hospital Heidelberg · NCT04613388 · Data updated 2026-11-12

This study tests if proton therapy can effectively treat young patients with mediastinal lymphoma while causing fewer side effects compared to traditional radiation methods.

More Primary Mediastinal Large B-cell Lymphoma (PMBCL) trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorUniversity Hospital Heidelberg
Academic / other
Drugs / interventionsradiation
Locations1 site (Heidelberg)
StatusRecruiting
StartedAugust 1, 2018
Main results expectedAugust 1, 2030
Study endsAugust 1, 2031
Registry record updatedApril 29, 2026
Trial IDNCT04613388 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older with histologically confirmed lymphoma requiring mediastinal radiotherapy.

Probably not a fit

Patients under 18 years old or those who do not consent to participate will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to document the effectiveness and side effects of proton radiotherapy in patients with mediastinal lymphoma. It focuses on reducing therapy-associated toxicity, particularly in young patients who are at risk for long-term complications from conventional radiation methods. By utilizing modern radiation techniques like proton therapy, the study seeks to minimize radiation exposure to critical organs such as the heart and lungs. Data collected will help inform future treatment planning and feasibility for this patient population.

Why it matters

Potential benefit: If successful, this study could lead to safer treatment options for lymphoma patients, reducing long-term side effects associated with radiation therapy.

How similar studies have gone: Other studies have shown promising results with proton therapy in reducing side effects, indicating a potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Histologically confirmed lymphoma according to WHO

* Patient consent
* Patient age ≥18 years.
* Presence of the need for mediastinal radiotherapy and the presumed benefit of mediastinal radiotherapy using protons in comparison to photon radiation (e.g. improved heart, lungs, and breast protection compared to photon radiation).
* Ability of the patient to give consent

Exclusion Criteria:

Age \<18 years

* Non-consent of the patient to the disclosure of his data
* Cancellation of the patient's participation in the study

Where it's running

  • University Hospital Heidelberg
    Heidelberg, Germany
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Proton Therapy for Mediastinal Lymphoma in Denmark

    This study tests whether using proton therapy for mediastinal lymphoma can lower late-toxicity risk compared with photon therapy in adults.

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  • Treatment of relapsed large B-cell lymphoma with WZTL-002 CAR T-cells

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.