Observing symptoms of Frey's syndrome

Typical and Atypical Symptoms of Frey's Syndrome: a Pilot Study

Observational Fondazione Policlinico Universitario Agostino Gemelli IRCCS · NCT05738395

This study looks at how common and severe symptoms like sweating and pain are in people with Frey's syndrome, especially those who have parotid tumors.

Quick facts

Study typeObservational
Enrollment20 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other
Drugs / interventionsradiation
Locations1 site (Roma)
Trial IDNCT05738395 on ClinicalTrials.gov

What this trial studies

This observational study aims to describe the prevalence and severity of symptoms associated with Frey's syndrome, particularly in patients with parotid neoplasms. Participants will be asked about the presence of symptoms such as gustatory sweating, flushing, itching, paresthesia, and pain, as well as the severity of these symptoms. The study will focus on identifying the affected areas and the intensity of each symptom to better understand the condition's impact on patients.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals clinically diagnosed with Frey's syndrome.

Not a fit: Patients who have already received treatment for Frey's syndrome or have a history of radiation therapy in the head-neck area may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the understanding of Frey's syndrome, leading to improved management and treatment options for affected patients.

How similar studies have performed: While this study focuses on observational data, similar studies have previously highlighted the prevalence of Frey's syndrome, indicating a foundation for understanding its symptoms.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Clinical diagnosis of Frey's syndrome

Exclusion Criteria:

* Patients already treated for Frey syndrome, with any therapy

  * History of radiation therapy of the head-neck district
  * Patients affected by neurologic diseases

Where this trial is running

Roma

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Parotid Neoplasms
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.