Observing outcomes of high-precision radiotherapy in metastatic breast cancer
Official title: Prospective Observational Study on Outcome of High-precision Hypo-fractionated Radiotherapy in Metastatic Breast Cancer (PRECISE-M)
Run by Samsung Medical Center · NCT05907681 · Data updated 2026-11-12
This study looks at how well high-precision radiation treatments work for people with metastatic breast cancer who have already had or are about to receive advanced radiation therapies.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years to 100 Years |
| Sex | Women only |
| Enrollment | 400 (estimated) |
| Sponsor | Samsung Medical Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | May 11, 2023 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2033 |
| Registry record updated | June 29, 2025 |
| Trial ID | NCT05907681 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with histologically confirmed breast cancer who have distant metastasis and are undergoing high-precision radiation therapy.
✕Probably not a fit
Patients who are unable to adhere to the study protocol will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study observes the outcomes of high-precision hypo-fractionated radiotherapy in patients with metastatic breast cancer. It focuses on individuals who have undergone or are scheduled to receive advanced radiation therapies such as IMRT, SBRT, or proton therapy. The study aims to gather data on the effectiveness and safety of these treatment approaches in managing distant metastasis in breast cancer patients.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into optimizing radiotherapy for patients with metastatic breast cancer, potentially improving treatment outcomes.
How similar studies have gone: While this approach is observational, similar studies have shown promising outcomes with high-precision radiotherapy techniques in cancer treatment.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * histologically confirmed breast cancer * presence of distant metastasis * radiation therapy using IMRT, SBRT, or proton therapy is done or planned * Able and willing to comply with the study protocol Exclusion Criteria: * unable to adhere to the study protocol
Where it's running
-
Samsung Medical Center
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Haeyoung Kim — Samsung Medical Center
- Study coordinator: Haeyoung Kim
- Email: haeyoung0131.kim@samsung.com
- Phone: +82-02-3410-2612
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
PRT13722 in advanced HR+/HER2- breast cancer
This early study tests PRT13722, by itself and with standard therapies, to see if it is safe and has any signs of activity in adults with HR+/HER2- breast cancer who have progressed on prior treatments.
-
Entinostat with Pyrotinib and Endocrine Therapy in HER2-positive, HR-positive Advanced Breast Cancer after Trastuzumab Failure
This study tests whether adding entinostat to pyrotinib and hormone therapy is safe and helps patients with advanced HR+/HER2+ breast cancer who progressed after trastuzumab.
-
UGT1A1 gene and side effects from certain antibody-drug treatments for advanced breast cancer
This project will test whether common UGT1A1 gene variants explain who gets worse side effects from antibody-drug conjugates (sacituzumab-govitecan, trastuzumab-deruxtecan, or datopotamab-deruxtecan) in adults with advanced breast cancer.
-
Generative AI Education Tool for Breast Cancer Care
Researchers are testing an AI-powered teaching tool to help adults with breast cancer understand their care while receiving treatment from UCSF physicians.
-
Pulsed Electric Field Ablation for Metastatic Breast Cancer
This trial tests a one-time pulsed electric field ablation to treat superficial metastatic breast cancer lesions in adults, guided by imaging.
-
Adaptive biomarker-driven therapies for metastatic breast cancer
This trial tests whether matching targeted drug combinations to tumor biomarkers helps people with ER+/HER2- or triple-negative metastatic breast cancer who are starting second-line treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.