Observing MRD's role in local treatment for oligometastatic breast cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the correlation between minimal residual disease (MRD) levels and prognosis in patients with oligometastatic breast cancer who have undergone local treatment. Participants will provide medical history and demographic information, undergo imaging and MRD testing prior to treatment, and continue with assessments every three months throughout the study. The goal is to identify which patients may benefit from localized treatment based on their MRD levels and to develop individualized treatment plans.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Histologically or cytologically confirmed breast cancer.
2. Previously confirmed metastatic breast cancer by imaging.
3. Eastern Cooperative Oncology Group (ECOG) physical status score of 0-2. (4) Age ≥ 18 years at the time of signing the informed consent form. (5) Subjects willing and able to comply with the study protocol throughout the study period.

(6) Female subjects of childbearing potential must agree to use a highly effective method of contraception during the study.

(7) Voluntarily agree to and sign a written informed consent form and be willing and able to comply with all aspects of the trial protocol, which can be withdrawn by the patient at any time without prejudice.

Exclusion Criteria:

1. Patients with active/refractory infections that require ongoing anti-infective therapy.
2. Severe cardiovascular compromise (history of congestive heart failure greater than New York Heart Association (NYHA) class II), unstable angina or myocardial infarction within the past 6 months, or severe arrhythmia.
3. Subjects with allogeneic organ transplants requiring immunosuppressive therapy. (4) Subjects known to be human immunodeficiency virus (HIV) positive.

5\) Subjects with a prior malignancy other than breast cancer, cervical cancer in situ, and non-melanoma skin cancer, unless the prior malignancy has been previously diagnosed and definitively treated for at least 5 years without evidence of subsequent recurrence.

6\) Any medical condition that, in the opinion of the Investigator, makes the subject unsuitable for entry into the study.

Where it's running

• The First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Zheng Lv
• Email: 826871727@qq.com
• Phone: +8618844173475

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.