Observing micro-movements in patients with prolonged disorders of consciousness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate micro-movements in patients with prolonged disorders of consciousness using a neuropsychological paradigm model. It will assess the patients' levels of consciousness and classify them accurately while screening for cognitive-motor dissociation to enhance prognosis. Participants will undergo evaluations using the CRS-R scale, and their micro-movement responses to emotional stimuli will be recorded alongside EEG and MRI data. The study will involve approximately 178 participants, including both patients and healthy controls, with follow-up assessments over a six-month period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
2. Aged between 18 and 80 years;
3. Stable vital signs;
4. Voluntary participation of family members with signed informed consent;
5. Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.

Exclusion Criteria:

1. Locked-in syndrome;
2. Contraindications for EEG examination;
3. Contraindications for MRI scanning, such as the presence of internal metallic implants;
4. Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.

Where it's running

• First Affiliated Hospital,Zhejiang University
  Hanzhou, Zhejiang, China Recruiting

Study contacts

• Study coordinator: Zhuolin He
• Email: hezhuolin@zju.edu.cn
• Phone: 15990049962

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Measuring brain activity to assess consciousness recovery in ICU patients

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• Investigating brain activity and consciousness in patients with severe brain injuries

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  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06426615

• Understanding micro-expressions in patients with prolonged disorders of consciousness

  This study is trying to see if watching emotional videos can help understand the tiny facial expressions of patients with prolonged disorders of consciousness and improve how doctors assess their awareness.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06088628

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.