Observing kidney function changes in living kidney transplant pairs
Observation of Alterations in Kidney Function, Immune System and Gut Mircobiota After Living Donor Kidney Transplantation
This study looks at how kidney function and other health factors change in living kidney donors and their recipients who live together before and after the transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Charite University, Berlin, Germany Academic / other |
| Locations | 1 site (Berlin) |
| Trial ID | NCT05570929 on ClinicalTrials.gov |
What this trial studies
This observational study examines kidney function, immune response, and gut microbiota in pairs of living kidney donors and recipients who reside together. Participants will be monitored before and 24 weeks after the kidney transplant, with assessments of kidney function, body composition, blood pressure, gut microbiome diversity, and immune cell states. The study aims to understand the interactions between these factors and their impact on kidney health post-transplant.
Who should consider this trial
Good fit: Ideal candidates are individuals with a Body Mass Index between 18.5 and 34.9 kg/m2 who are planned living kidney donors or recipients.
Not a fit: Patients with significant heart, lung, liver, or kidney diseases, or those with acute infections or a vegan diet may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of kidney transplant outcomes and improve post-transplant care for patients.
How similar studies have performed: While similar observational studies have been conducted, this specific multi-omics approach in living donor-recipient pairs is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Body-Mass-Index 18,5 - 34,9 kg/m2 * Planned living kidney donation / transplantation Exclusion Criteria: * Clinically relevant heart, lung, liver, and kidney diseases * Postoperative phase * Acute infections * Vegan diet * Change of body weight of more than 10% in the month prior to study entry * Known drug or alcohol abuse
Where this trial is running
Berlin
- Experimental and Clinical Research Center — Berlin, Germany (Recruiting)
Study contacts
- Principal investigator: Nicola Wilck, MD — Charite University, Berlin, Germany
- Study coordinator: Hendrik Bartolomaeus, MD
- Email: hendrik.bartolomaeus@charite.de
- Phone: +49 30 450 540 464
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.