Observing immune response and viral shedding in Oropouche virus infection
Official title: OBSERVATIONAL STUDY ON VIRAL SHEDDING AND IMMUNOLOGICAL RESPONSE OF OROPOUCHE VIRUS
Run by IRCCS Sacro Cuore Don Calabria di Negrar · NCT06892015 · Data updated 2026-11-12
This study looks at how the immune system reacts and how long the Oropouche virus stays in the body of people who have tested positive for it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | IRCCS Sacro Cuore Don Calabria di Negrar Academic / other |
| Locations | 1 site (Negrar, VR) |
| Status | Recruiting |
| Started | December 19, 2024 |
| Main results expected | April 2026 |
| Study ends | October 2026 |
| Registry record updated | May 18, 2025 |
| Trial ID | NCT06892015 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who have tested positive for Oropouche virus.
✕Probably not a fit
Patients who do not provide informed consent or those who have not tested positive for Oropouche virus will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to describe the immune response to Oropouche Virus (OROV) and the duration of viral RNA shedding in patients. It involves both retrospective and prospective enrollment of participants who have tested positive for OROV through RT-PCR. Sequential samples will be collected and analyzed using RT-PCR across different biological matrices to gather comprehensive data on the viral shedding process and immune response over time.
Why it matters
Potential benefit: If successful, this study could enhance understanding of Oropouche virus infection, leading to improved management and treatment strategies for affected patients.
How similar studies have gone: While there may be limited studies specifically on Oropouche virus, similar observational studies on viral infections have shown success in understanding immune responses and viral dynamics.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients resulted positive to the RT-PCR for OROV; * informed consent to the participation to the study and to personal data's treatment and/or donation of residual samples to Tropika Biobank; * patients ≥ 18 years old. Exclusion Criteria • lack of signed informed consent.
Where it's running
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IRCCS Sacro Cuore Don Calabria
Negrar, Vr, Italy Recruiting
Study contacts
- Study coordinator: Elvia Malo
- Email: ricerca.clinica@sacrocuore.it
- Phone: +390456013111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.