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Observing heart failure management practices

BRING-UP 3 Heart Failure

Observational Heart Care Foundation · NCT06279988

This study looks at how well doctors are following guidelines to treat patients with heart failure and sees if educational support can improve care over time.

Quick facts

Study typeObservational
Enrollment10000 (estimated)
Ages18 Years and up
SexAll
SponsorHeart Care Foundation Academic / other
Locations187 sites (Casale Monferrato, AL and 186 other locations)
Trial IDNCT06279988 on ClinicalTrials.gov

What this trial studies

This observational study aims to evaluate adherence to guideline recommendations for managing patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and to monitor treatment patterns in patients with both acute and chronic heart failure. It involves a prospective, multicenter approach across various Italian cardiology centers, with data collection occurring over two enrollment phases. Each phase includes educational interventions to address gaps in clinical practice and follow-up assessments at 6 and 12 months to evaluate treatment modifications and outcomes.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with any level of ejection fraction who are experiencing chronic or acute heart failure.

Not a fit: Patients with active neoplasia or severe diseases that significantly compromise life expectancy may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could improve adherence to treatment guidelines and enhance patient outcomes in heart failure management.

How similar studies have performed: Other studies have shown success in improving heart failure management through adherence to guidelines, making this approach both relevant and potentially impactful.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Age ≥18 years old.
2. Males and females at birth.
3. Any ejection fraction level (level of ejection fraction measured in the 6 months preceding enrollment).
4. Ambulatory chronic HF or Hospitalized de-novo or worsening HF.
5. Signed informed consent

Diagnosis will be made by the local attending physician following the ESC guidelines recommendations.

Exclusion Criteria:

1. Active neoplasia or very severe disease compromising short-medium term life expectancy.
2. Participation in interventional studies.
3. Patients already enrolled into the study from another participating center or in the previous enrolling phase.

Where this trial is running

Casale Monferrato, AL and 186 other locations

+137 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Heart Failure
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.